neuroligin X/Y Inhibitors
The chemical class of neuroligin X/Y Inhibitors encompasses a diverse range of small molecules that target various signaling pathways and cellular processes involved in the regulation of neuroligin X/Y expression and function. These inhibitors act on different molecular targets, including enzymes such as histone deacetylases (HDACs), kinases like Janus kinases (JAKs) and glycogen synthase kinase 3 (GSK-3), receptors such as vascular endothelial growth factor receptor (VEGFR) and transforming growth factor beta (TGF-β) receptor, and other proteins like guanine nucleotide exchange factors (GEFs) and proteasome.
The inhibition of these targets can modulate neuroligin X/Y levels, synaptic plasticity, and neuronal function. For example, inhibitors of HDACs, such as MS-275 and CUDC-907, can alter the transcriptional regulation of genes involved in neuroligin X/Y signaling pathways. Similarly, compounds like Ruxolitinib and SB216763 target kinases that play crucial roles in neuroligin X/Y-mediated cellular responses. Additionally, inhibitors of growth factor receptors like Axitinib and Sunitinib can indirectly influence neuroligin X/Y expression through modulation of downstream signaling cascades. Overall, neuroligin X/Y inhibitors represent a valuable tool for studying the molecular mechanisms underlying synaptic function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NLG919 | 1402836-58-1 | sc-478118 | 10 mg | $352.00 | ||
NLG919 is a potent inhibitor of the indoleamine 2,3-dioxygenase (IDO) enzyme, which can regulate neuroligin X/Y expression and function. | ||||||
PI3K/HDAC Inhibitor | 1339928-25-4 | sc-364584 sc-364584A | 5 mg 10 mg | $340.00 $462.00 | ||
CUDC-907 inhibits histone deacetylases (HDACs) and phosphoinositide 3-kinase (PI3K), both of which can modulate neuroligin X/Y levels and activity. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 is a selective inhibitor of the guanine nucleotide exchange factor (GEF) that activates the small GTPase Ras, which can indirectly affect neuroligin X/Y signaling pathways. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a potent inhibitor of class I histone deacetylases (HDACs), which can regulate the transcription of genes involved in neuroligin X/Y function. | ||||||
Dovitinib, Free Base | 405169-16-6 | sc-396771 sc-396771A | 10 mg 25 mg | $170.00 $350.00 | ||
GW441756 inhibits TrkA, a receptor for nerve growth factor (NGF), which can regulate neuroligin X/Y expression and synaptic plasticity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a potent proteasome inhibitor, which can affect the degradation of proteins involved in neuroligin X/Y signaling cascades. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib targets Janus kinases (JAKs), which play a role in neuroligin X/Y signaling pathways, thereby modulating its activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a selective inhibitor of glycogen synthase kinase 3 (GSK-3), which can regulate neuroligin X/Y expression and synaptic function. | ||||||
AG 1024 | 65678-07-1 | sc-205907 | 1 mg | $105.00 | 22 | |
AG-1024 inhibits insulin-like growth factor 1 receptor (IGF-1R), which can influence neuroligin X/Y signaling and synaptic plasticity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 inhibits transforming growth factor beta (TGF-β) receptor, which can modulate neuroligin X/Y expression and synaptic function. | ||||||