Molecular structure of Dovitinib, Free Base, CAS Number: 405169-16-6
Dovitinib, Free Base (CAS 405169-16-6)
Alternate Names:
4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
Application:
Dovitinib, Free Base is the free base form of an FGFR inhibitor
CAS Number:
405169-16-6
Molecular Weight:
392.43
Molecular Formula:
C21H21FN6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dovitinib, Free Base, is the non-salt form of dovitinib, lactate salt (sc-396753). Dovitinib is a multitargeted growth factor receptor kinase inhibitor to VEGFR, FGFR3, PDGFR and c-KIT.
Dovitinib, Free Base (CAS 405169-16-6) References
- CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. | Trudel, S., et al. 2005. Blood. 105: 2941-8. PMID: 15598814
- TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer. | Sohn, SH., et al. 2021. J Cancer. 12: 6356-6362. PMID: 34659525
- Preformulation studies of dovitinib free base: Solubility, lipophilicity and stability. | Sripetch, S., et al. 2022. Int J Pharm. 619: 121721. PMID: 35398252
- Cyclodextrins and Drug Membrane Permeation: Thermodynamic Considerations. | Sripetch, S., et al. 2022. J Pharm Sci. 111: 2571-2580. PMID: 35487262
Inhibitor of:
ALK-1, bFGF, c-Kit, Cnpy1, E230008N13Rik, eIF3δ, Endo180, FGF-BP3, FGFR-3, FIBP, Flg, Flt-3/Flk-2, FRS3, GFR-1, IDAS, neuroligin X/Y, PDGFR, PIG-U, Protein Z, RETL2, SCF, SEMA3A, and VEGF-C.Activator of:
β-FR, Bek, FGF-2, FLTR3, and PRAT4B_Cnpy4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dovitinib, Free Base, 10 mg | sc-396771 | 10 mg | $170.00 | |||
Dovitinib, Free Base, 25 mg | sc-396771A | 25 mg | $350.00 |