ZCL278 (CAS 587841-73-4)
Alternate Names:
ZCL 278 ZCL-278 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenylcarbamothioyl)acetamide
CAS Number:
587841-73-4
Molecular Weight:
584.90
Molecular Formula:
C21H19BrClN5O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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ZCL278 (CAS 587841-73-4) References
- Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. | Friesland, A., et al. 2013. Proc Natl Acad Sci U S A. 110: 1261-6. PMID: 23284167
- Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. | Chou, YY., et al. 2016. J Virol. 90: 4494-4510. PMID: 26912630
- Intersectin-Cdc42 interaction is required for orderly meiosis in porcine oocytes. | Li, X., et al. 2019. J Cell Physiol. 234: 7492-7497. PMID: 30478952
- Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth. | Aguilar, BJ., et al. 2019. Cancer Biol Ther. 20: 740-749. PMID: 30849276
- Visualizing DC morphology and T cell motility to characterize DC-T cell encounters in mouse lymph nodes under mTOR inhibition. | Lin, Q., et al. 2019. Sci China Life Sci. 62: 1168-1177. PMID: 31016533
- Vav2 lacks Ca2+ entry-promoting scaffolding functions unique to Vav1 and inhibits T cell activation via Cdc42. | Fray, MA., et al. 2020. J Cell Sci. 133: PMID: 31974114
- Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4. | Wu, Y., et al. 2021. Stem Cell Res Ther. 12: 387. PMID: 34233723
- Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. | Wen, D., et al. 2022. Microbes Infect. 24: 104931. PMID: 35026388
- ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42. | Zhang, X., et al. 2022. J Exp Clin Cancer Res. 41: 230. PMID: 35869555
- Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer. | Liang, B., et al. 2024. Cancer Lett. 587: 216702. PMID: 38336288
Inhibitor of:
β2-chimaerin, 4931406P16Rik, A430078G23Rik, A730069N07Rik, ARHGAP (Rho GTPase activating protein), ARHGAP15, ARHGAP21, ARHGAP23, ARHGAP36, ARHGAP39, ARHGAP40, ARHGEF10, ARHGEF17, ARHGEF19, ARHGEF37, ARHGEF38, ARHGEF5_Arhgef5, ARL14EPL, ARL16, ARL4D, ARL7, ARNO, Atlastin, BC055111, BRAG2, Cdc42EP2, Cdc42EP3, Cdc42EP4, Cdc42EP5, CdGAP, Centaurin γ3, CIP4, DBC-2, DENND2C, DENND5B, DENND6B, DIRAS1, DIRAS2, DOCK 2, DOCK 6, DOCK 7, E130112L23Rik, Elmo1, FAM109A, FGD6, FRMD3, GBP8, GIMAP3, GIMAP9, GIN1, Gm1527, IPCEF1, IQSEC2, KBTBD6, Lamin B receptor, Lbc, Ly-GDI, MCF2L2, MRCKγ, neuroligin X/Y, OTTMUSG00000005723, PAR-6, PARD3A, PIPK III, PLEKHG1, PLEKHG2, PLEKHG3, PLEKHG5, PLEKHG6, Rab 11A, Rab 16, Rab 27b, Rab 35, Rab 38, Rab 3D, Rab 43, Rab 6, Rab 7L1, Rab 9B, RAB3IL1, rabphilin-11, Rac 2, Radixin, RAPGEF5, Repac, RGL3, Rho GAP p190, Rho H, Rho V, RHOBTB1, Rhotekin, Rhotekin 2, RILPL1, RILPL2, RIN3, RIP/Rab, Rnd1, RPGRIP1L, SLIT-ROBO Rho GTPase activating protein (SRGAP), SYDE1, TBC1D13, TBC1D2, TBC1D3, TBC1D30, TC10, Vav3, and WRCH1.Activator of:
γPAK, ARAP1, ARHGAP10, ARHGAP11A, ARHGAP6, ARHGEF38, C3orf34_1500031L02Rik, Cdc42, CED-5, DOCK 180, Gm949, MON1B, PARD6B, RAb 19B, Rab 1A, rac1, SNX18, WDR41, and XPLN.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZCL278, 10 mg | sc-507369 | 10 mg | $115.00 |