NELF-E Activators
The chemical class of NELF-E activators encompasses a diverse array of compounds strategically designed to target various signaling pathways intricately involved in transcriptional regulation. These activators exert their effects by either modulating the acetylation status of histones or inhibiting specific signaling pathways, resulting in the heightened recruitment of NELF-E to the transcription elongation complex. For instance, bromodomain inhibitors like JQ1 and PFI-1 activate NELF-E through the modulation of histone acetylation. Similarly, compounds such as Curcumin, Luteolin, Thymoquinone, and Genistein activate NELF-E by selectively inhibiting crucial signaling pathways like NF-κB, JNK, and MAPK, respectively.
The significance of these activators lies in their role as invaluable tools for unraveling the intricate regulatory mechanisms governing NELF-E and its impact on transcriptional elongation. By offering insights into the specific biochemical and cellular pathways influenced by NELF-E, this chemical class enhances our comprehension of the broader landscape of transcriptional regulation and the nuanced control of gene expression. Through their targeted actions on key molecular players, these activators provide researchers with the means to dissect the detailed interplay between NELF-E and the transcriptional machinery. This deeper understanding, facilitated by the use of these compounds, contributes to advancing our knowledge of the molecular intricacies that govern gene expression, paving the way for more precise manipulation and modulation of transcriptional processes in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain inhibitor, activates NELF-E by modulating the acetylation status of histones. By targeting bromodomain-containing proteins, JQ1 enhances the recruitment of NELF-E to the transcription elongation complex, facilitating the release of RNA Pol II and promoting gene expression. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
RVX-208, a BET inhibitor, indirectly activates NELF-E by disrupting the interaction between BET proteins and acetylated histones. This disruption leads to enhanced NELF-E association with the transcription elongation complex, favoring the regulation of RNA Pol II elongation and promoting gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates NELF-E by inhibiting the NF-κB pathway. Through its anti-inflammatory properties, curcumin reduces NF-κB activation, promoting NELF-E recruitment to the transcription elongation complex. This modulation influences RNA Pol II elongation, leading to enhanced gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberanilohydroxamic acid (SAHA), an HDAC inhibitor, activates NELF-E by increasing histone acetylation. SAHA-mediated histone acetylation facilitates the association of NELF-E with the transcription elongation complex, positively impacting RNA Pol II elongation and gene expression. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin activates NELF-E by inhibiting the JNK signaling pathway. Through its anti-inflammatory effects, luteolin reduces JNK activation, promoting the recruitment of NELF-E to the transcription elongation complex. This modulation influences RNA Pol II elongation, leading to enhanced gene expression. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone activates NELF-E by inhibiting the NF-κB pathway. Through its anti-inflammatory properties, thymoquinone reduces NF-κB activation, promoting NELF-E recruitment to the transcription elongation complex. This modulation influences RNA Pol II elongation, leading to enhanced gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates NELF-E by inhibiting the mTOR pathway. By reducing mTOR activation, resveratrol enhances the recruitment of NELF-E to the transcription elongation complex, influencing RNA Pol II elongation and promoting gene expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol activates NELF-E by inhibiting the NF-κB pathway. Through its immunomodulatory effects, vitamin D3 reduces NF-κB activation, promoting the recruitment of NELF-E to the transcription elongation complex. This modulation influences RNA Pol II elongation, leading to enhanced gene expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates NELF-E by inhibiting the MAPK pathway. Through its anti-inflammatory properties, genistein reduces MAPK activation, promoting NELF-E recruitment to the transcription elongation complex. This modulation influences RNA Pol II elongation, leading to enhanced gene expression. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
PFI-1, a bromodomain inhibitor, activates NELF-E by modulating the acetylation status of histones. By targeting bromodomain-containing proteins, PFI-1 enhances the recruitment of NELF-E to the transcription elongation complex, facilitating the release of RNA Pol II and promoting gene expression. | ||||||