NELF-A Activators
NELF-A activators are a class of small molecules that play a critical role in regulating gene expression and transcriptional elongation in cells. These compounds target the NELF-A protein, also known as Negative Elongation Factor-A, which is an essential component of the NELF complex. The NELF complex is involved in the control of RNA polymerase II-mediated transcription by acting as a transcriptional elongation checkpoint. NELF-A activators modulate the activity of NELF-A, ultimately influencing the rate of transcriptional elongation and the expression of specific genes.
At the molecular level, NELF-A activators typically interact with NELF-A protein, leading to conformational changes that affect its binding affinity with RNA polymerase II. This interaction can result in the release of RNA polymerase II from the promoter-proximal pause sites, allowing it to progress along the gene, thereby promoting transcriptional elongation. NELF-A activators are a valuable tool in research for dissecting the intricacies of transcriptional regulation. They offer scientists a means to selectively manipulate the expression of genes of interest, helping to unravel the complex mechanisms that govern gene expression. Understanding the function of NELF-A activators and their impact on transcriptional elongation is crucial for advancing our knowledge of cellular processes and may have implications in various fields of molecular biology and biotechnology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO may enhance the expression of NELF-A through its role in altering cell permeability, potentially leading to changes in intracellular conditions and subsequently influencing gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-azacytidine can lead to demethylation of DNA and potentially activate the transcription of genes, including NELF-A, that might be silenced due to methylation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA inhibits histone deacetylases, leading to an open chromatin state and potentially promoting the transcription of various genes, including NELF-A. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Like TSA, sodium butyrate acts as a histone deacetylase inhibitor, potentially inducing the expression of genes like NELF-A by promoting a more transcriptionally active chromatin state. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, plays a crucial role in cell growth and differentiation, and has been shown to influence the expression of numerous genes, potentially including NELF-A. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has been shown to have various biological effects, including potential modulation of gene expression. It might induce the expression of NELF-A through its antioxidative properties or via other signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As a polyphenolic compound found in grapes, resveratrol has been studied for its potential to modulate gene expression. It might enhance NELF-A expression through pathways related to stress response or cellular protection. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane is known for its potential to influence gene expression, particularly genes involved in detoxification and antioxidant responses, potentially including NELF-A. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, is known for its anti-inflammatory and antioxidant properties. It may influence the expression of various genes, potentially including NELF-A, through its interaction with signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase and increases cAMP levels, potentially leading to changes in gene expression, including the induction of NELF-A expression. | ||||||