ND4L Activators
ND4L activators encompass a broad spectrum of chemical compounds that, while not directly interacting with ND4L, modulate various cellular signaling pathways and thus can indirectly influence the activity of ND4L. These chemicals operate through diverse mechanisms, affecting a range of cellular functions and processes. The class includes compounds like Forskolin and Dibutyryl-cAMP, both known for their role in elevating intracellular cAMP levels, thereby potentially influencing PKA activity. This alteration in PKA activity is significant as it can modify the phosphorylation state of various proteins, some of which might be in signaling pathways intersecting with those regulating ND4L. Similarly, compounds such as PMA act on protein kinase C, which is a pivotal player in numerous signaling cascades. By activating PKC, PMA may indirectly modulate pathways that cross-talk with those involving ND4L, thereby influencing its activity.
In addition to these, the class includes specific inhibitors like LY294002 and Rapamycin, known for their roles in inhibiting key signaling pathways like PI3K/AKT and mTOR, respectively. These inhibitors, by altering the dynamics of these pathways, can indirectly impact ND4L. For instance, the inhibition of PI3K/AKT pathway by LY294002 may lead to changes in cellular processes that intersect with ND4L's regulatory network. Moreover, compounds like Retinoic Acid and Sodium Butyrate, which influence gene expression patterns, highlight the importance of transcriptional regulation in this context. By altering the expression of genes within pathways associated with ND4L, these compounds can indirectly modulate its activity. This is also true for Insulin, which through its receptor, initiates a series of downstream signaling events potentially intersecting with ND4L-related pathways.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels in cells. This rise in cAMP can enhance protein kinase A (PKA) activity, which may indirectly influence ND4L activation by altering phosphorylation states of related proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can modulate various signaling pathways. Through PKC activation, it may influence ND4L by altering downstream signaling cascades that intersect with ND4L's regulatory mechanisms. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Increases intracellular calcium levels, potentially affecting calcium-dependent signaling pathways. This change could indirectly impact ND4L's activity through pathways sensitive to calcium signaling fluctuations. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor, which can alter gene expression patterns. This might affect ND4L by changing the expression of genes in pathways linked to ND4L activity, thereby modulating its function. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Activates the insulin receptor and associated signaling pathways. This could influence ND4L indirectly by modifying metabolic or growth-related signaling pathways that interact with ND4L's regulatory network. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Another calcium ionophore, which raises intracellular calcium levels and can thereby influence calcium-dependent signaling pathways, potentially affecting ND4L indirectly. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences gene expression by activating retinoic acid receptors. This could indirectly affect ND4L by modulating the expression of genes involved in pathways where ND4L plays a role. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, which is involved in numerous signaling pathways, including Wnt signaling. While Wnt is excluded, the inhibition of GSK-3β might indirectly influence pathways involving ND4L. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that can penetrate cell membranes, raising intracellular cAMP levels and potentially affecting pathways related to PKA, which might indirectly influence ND4L. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that indirectly affects various signaling pathways including AKT signaling. This could impact ND4L's activity indirectly by altering the dynamics within these pathways. | ||||||