MT-ND (mitochondrial NADH dehydrogenase) Inhibitors
The MT-ND family, consisting of mitochondrially encoded NADH dehydrogenase genes, plays a pivotal role in the mitochondrial electron transport chain (ETC), essential for cellular energy production. These genes encode subunits of Complex I, the largest and first enzyme complex in the ETC, which initiates the process of oxidative phosphorylation by transferring electrons from NADH to ubiquinone. Complex I is integral in creating a proton gradient across the inner mitochondrial membrane, a critical step for ATP synthesis. The MT-ND genes contribute to the formation of the core structure and functional sites of Complex I, ensuring efficient electron transfer and coupling with proton translocation. Furthermore, the MT-ND family is involved in generating reactive oxygen species (ROS) as by-products of electron transport, linking mitochondrial function to cellular signaling pathways related to stress response and apoptosis.
Targeting NADH dehydrogenase (Complex I) for disruption or inhibition using small molecules is a fundamental approach in mitochondrial biology to understand the mechanism of ETC and its impact on cellular metabolism. Inhibition of Complex I allows researchers to investigate the consequences of reduced electron transport and consequent decrease in the mitochondrial membrane potential and ATP synthesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is a natural compound that inhibits mitochondrial complex I. It acts by binding to the iron-sulfur clusters within the complex, leading to reduced electron transfer and energy production. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A is a natural antibiotic and a potent inhibitor of complex I. It mimics the action of ubiquinone, interfering with electron transfer. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Methylene blue acts as an alternative electron acceptor in the mitochondrial respiratory chain, indirectly modulating the activity of complex I. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO can indirectly affect mitochondrial function by altering membrane permeability and fluidity, potentially influencing complex I activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Though primarily targeting complex III, Antimycin A can cause a compensatory effect on complex I, indirectly impacting NADH dehydrogenases activity. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
TTFA is a specific inhibitor of mitochondrial complex II but may have secondary effects on complex I, indirectly influencing NADH dehydrogenases. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits mitochondrial complex II, which can have downstream effects on complex I and NADH dehydrogenases. | ||||||
Atpenin A5 | 119509-24-9 | sc-202475 sc-202475A sc-202475B sc-202475C | 250 µg 1 mg 10 mg 50 mg | $140.00 $424.00 $2652.00 $12240.00 | 17 | |
Atpenin A5 is a potent inhibitor of mitochondrial complex II, potentially affecting the overall mitochondrial respiratory chain including NADH dehydrogenases. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase in complex IV, which could lead to altered function of complex I and indirect inhibition of NADH dehydrogenases. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
While targeting ATP synthase (complex V), Oligomycin’s action can lead to an increased proton gradient, indirectly affecting complex I and NADH dehydrogenases | ||||||