NCOAT Inhibitors
Items 1 to 10 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Streptozotocin (U-9889) | 18883-66-4 | sc-200719 sc-200719A | 1 g 5 g | $110.00 $510.00 | 152 | |
Streptozotocin (U-9889) exhibits unique reactivity as an NCOAT, characterized by its ability to selectively alkylate DNA, particularly at the N7 position of guanine. This interaction leads to the formation of DNA adducts, which can trigger cellular stress responses. Its reaction kinetics reveal a rapid initial phase followed by slower, sustained interactions, influencing cellular signaling pathways. Additionally, its polar nature enhances solubility in aqueous environments, facilitating its distribution in biological systems. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a potential indirect inhibitor of NCOAT, exerting its effect through interference with the purinergic signaling pathway. By antagonizing P2 receptors, particularly P2X and P2Y receptors, suramin disrupts intracellular calcium signaling, which can indirectly influence NCOAT activity. | ||||||
(Z)-Pugnac | 132489-69-1 | sc-204415A sc-204415 | 5 mg 10 mg | $220.00 $373.00 | 3 | |
(Z)-Pugnac functions as an NCOAT, showcasing distinctive reactivity through its electrophilic nature, which allows it to engage in nucleophilic acyl substitution reactions. This compound exhibits a propensity for forming stable intermediates, influencing reaction kinetics and enhancing its reactivity profile. Its unique steric configuration promotes selective interactions with various nucleophiles, leading to diverse product formation. Furthermore, its moderate polarity aids in solvation, impacting its behavior in different environments. | ||||||
Thiamet G | 1009816-48-1 | sc-224307 sc-224307A | 1 mg 5 mg | $51.00 $94.00 | 1 | |
Thiamet G acts as an NCOAT, characterized by its robust electrophilic character that facilitates rapid nucleophilic attack. Its unique structural features enable it to form transient acyl-enzyme complexes, significantly influencing reaction pathways. The compound's high reactivity is complemented by its ability to stabilize transition states, which accelerates reaction kinetics. Additionally, its specific steric hindrance allows for selective interactions, enhancing its versatility in various chemical environments. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a potential indirect inhibitor of NCOAT, acting through the sirtuin pathway. By activating SIRT1, a member of the sirtuin family of deacetylases, resveratrol modulates cellular processes involved in NCOAT regulation. SIRT1-mediated deacetylation events may directly or indirectly affect NCOAT activity, contributing to the regulation of cellular functions influenced by NCOAT. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a potential indirect inhibitor of NCOAT through its action on the Bcr-Abl signaling pathway. As a tyrosine kinase inhibitor, imatinib disrupts aberrant signaling cascades, including those involving Bcr-Abl. The downstream effects on intracellular signaling events may indirectly influence NCOAT activity, potentially altering its phosphorylation status and enzymatic function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a potential indirect inhibitor of NCOAT, acting through the L-type calcium channels. By blocking these channels, nifedipine reduces intracellular calcium levels, which can indirectly impact NCOAT activity. Calcium-dependent signaling pathways that regulate NCOAT may be modulated by the altered calcium dynamics induced by nifedipine, influencing the enzyme's function and downstream cellular processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potential indirect inhibitor of NCOAT, acting through the PI3K-Akt signaling pathway. As a PI3K inhibitor, wortmannin disrupts the phosphorylation cascade mediated by PI3K, which may have downstream effects on NCOAT activity. The modulation of PI3K-Akt signaling can indirectly influence NCOAT function and cellular processes regulated by this enzyme. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG-490 (Tyrphostin B42) is a potential indirect inhibitor of NCOAT through its action on the JAK-STAT signaling pathway. By inhibiting JAK2, AG-490 interferes with the activation of STAT transcription factors. The downstream effects on STAT-dependent gene expression may indirectly impact NCOAT activity, contributing to the regulation of cellular processes influenced by NCOAT and the JAK-STAT pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a potential indirect inhibitor of NCOAT, acting through the mTOR signaling pathway. By inhibiting mTOR, rapamycin disrupts the signaling cascade involved in protein synthesis and cell growth. The downstream effects on mTOR-dependent processes may indirectly influence NCOAT activity, potentially altering its phosphorylation status and enzymatic function in response to changes in cellular nutrient and energy status. | ||||||