Thiamet G (CAS 1009816-48-1)
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Thiamet G is a potent and selective inhibitor of the enzyme O-GlcNAcase, which is involved in the post-translational modification of proteins by adding or removing N-acetylglucosamine (O-GlcNAc). This compound is widely used in the study of protein glycosylation processes and has been pivotal in elucidating the role of O-GlcNAcylation in various cellular functions and diseases. Researchers utilize Thiamet G to investigate how alterations in O-GlcNAcylation levels affect signal transduction, transcription, and the cell cycle, contributing to a deeper understanding of cellular regulation mechanisms. In neuroscience, Thiamet G aids in the exploration of the implications of O-GlcNAcylation in neurodegenerative diseases, as abnormal protein glycosylation is a characteristic feature in such disorders. Its application in basic biochemical research has also helped in the identification of proteins that undergo this modification and in the understanding of the dynamic nature of protein O-GlcNAcylation.
Thiamet G (CAS 1009816-48-1) References
- O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. | Liu, F., et al. 2004. Proc Natl Acad Sci U S A. 101: 10804-9. PMID: 15249677
- A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. | Yuzwa, SA., et al. 2008. Nat Chem Biol. 4: 483-90. PMID: 18587388
- Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction. | Hilgers, RH., et al. 2012. Am J Physiol Heart Circ Physiol. 303: H513-22. PMID: 22777418
- Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent paclitaxel. | Ding, N., et al. 2014. Biochem Biophys Res Commun. 453: 392-7. PMID: 25268318
- O-GlcNAcylation enhances the invasion of thyroid anaplastic cancer cells partially by PI3K/Akt1 pathway. | Zhang, P., et al. 2015. Onco Targets Ther. 8: 3305-13. PMID: 26635480
- Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling. | He, Y., et al. 2017. J Cereb Blood Flow Metab. 37: 2938-2951. PMID: 27864466
- O-GlcNAcylation promotes migration and invasion in human ovarian cancer cells via the RhoA/ROCK/MLC pathway. | Niu, Y., et al. 2017. Mol Med Rep. 15: 2083-2089. PMID: 28259907
- XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G. | Jiang, M., et al. 2017. Stroke. 48: 1646-1654. PMID: 28487326
- O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina. | Dierschke, SK., et al. 2019. J Biol Chem. 294: 5508-5520. PMID: 30733333
- Upregulated protein O-GlcNAcylation promoted functional and structural recovery of the contused spinal cord injury in rats by Thiamet-G treatment. | Liang, H., et al. 2019. Neurol Res. 41: 780-790. PMID: 31092134
- O-GlcNAcylation of light chain serine 12 mediates rituximab production doubled by thiamet G. | Kim, HY., et al. 2020. Bioprocess Biosyst Eng. 43: 863-875. PMID: 31980903
- Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. | Lu, S., et al. 2020. Circ Res. 126: e80-e96. PMID: 32134364
- Osteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment. | Takeuchi, T., et al. 2020. Biol Pharm Bull. 43: 1501-1505. PMID: 32999159
- Protein O-GlcNAcylation Promotes Trophoblast Differentiation at Implantation. | Ruane, PT., et al. 2020. Cells. 9: PMID: 33036308
- REM Sleep Deprivation Impairs Learning and Memory by Decreasing Brain O-GlcNAc Cycling in Mouse. | Kim, SM., et al. 2021. Neurotherapeutics. 18: 2504-2517. PMID: 34312767
- Structure-based discovery and development of novel O-GlcNAcase inhibitors for the treatment of Alzheimer's disease. | Li, X., et al. 2022. Eur J Med Chem. 238: 114444. PMID: 35588599
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiamet G, 1 mg | sc-224307 | 1 mg | $51.00 | |||
Thiamet G, 5 mg | sc-224307A | 5 mg | $94.00 |