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(Z)-Pugnac is an inhibitor of NCOAT (O-GlcNAcase), an enzyme which removes the N-acetylglucosamine moieties from 2-acetamido-2-deoxy-β-D-glucopyranose (O-GlcNAc) bound to proteins that were modified by O-GlcNAc. In addition, studies show that (Z)-Pugnac is the more potent inhibitor of O-GlcNAcase than its stereoisomer since it readily undergoes Beckmann rearrangement. Furthermore, (Z)-Pugnac increases the modification of proteins by GlcNAc in adipocytes and decreases insulin-stimulated 2-deoxyglucose (2DG) uptake and GLUT4 translocation in adipocytes, which implies that (Z)-Pugnac promotes insulin resistance in adipocytes. (Z)-Pugnac is an inhibitor of HEXA and HEXB.
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See how others have used (Z)-Pugnac. Click on the entry to view the PubMed entry .
PMID: # 28032764 Wang, Y. et al. 2017. J. Med. Chem. 60: 263-272.
PMID: # 26282597 Kumar, AB. et al. 2015. Clin. Chim. Acta. 451: 125-8.
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