Date published: 2026-4-1

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N-twist Activators

N-twist Activators represent a category of chemical compounds characterized by their ability to modulate specific molecular targets, often through a mechanism involving a conformational change, or twist, at the nitrogen atom within their molecular structure. These activators are typically organic molecules that contain one or more nitrogen atoms capable of engaging in such dynamic structural transformations. The core idea is that the twist around the nitrogen atom can influence the behavior of the entire molecule, which in turn affects its interaction with other molecules or molecular systems. This twisting action is not merely a physical rotation but often involves changes in electronic configuration that can have a significant impact on the molecule's reactivity and its ability to engage with specific chemical environments.

The design and study of N-twist Activators require a deep understanding of structure-activity relationships, as the precise arrangement of atoms and the electronic environment around the nitrogen atom are crucial for the desired molecular modulation to take place. These compounds can exhibit a wide range of behaviors based on the nature and degree of the twist, the substituents attached to the nitrogen, and the overall three-dimensional shape of the molecule. Researchers interested in the development and characterization of these activators must therefore employ a variety of analytical techniques, including but not limited to, NMR spectroscopy, X-ray crystallography, and computational modeling, to elucidate the structural parameters that govern their function. Notably, the N-twist phenomenon is a testament to the elegant complexity of chemical systems, where a single atomic motion can propagate significant changes throughout a molecular structure, leading to precise alterations in chemical properties and reactivity.

SEE ALSO...

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic Acid binds to retinoic acid receptors (RARs) which can regulate the expression of N-twist by binding to its promoter regions, thus enhancing its functional activity.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin activates adenylate cyclase, increasing cAMP levels which can lead to protein kinase A (PKA) activation. PKA can then phosphorylate transcription factors that enhance N-twist expression.

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$47.00
$136.00
$492.00
$4552.00
74
(7)

This cAMP analog can permeate cell membranes and activate PKA, which can then enhance the transcription and activity of N-twist.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC) which, through downstream signaling, can enhance the transcriptional activity of N-twist.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium inhibits glycogen synthase kinase 3 (GSK-3), which can lead to the stabilization and activation of β-catenin. β-catenin can translocate to the nucleus and enhance N-twist expression.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

This histone deacetylase inhibitor can increase acetylation of histones, leading to a more relaxed chromatin structure and potentially enhancing transcription of genes including N-twist.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

SB431542 inhibits TGF-β receptors, which can lead to altered SMAD signaling and upregulation of N-twist expression as a compensatory mechanism.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

As a PI3K inhibitor, LY294002 can affect the AKT pathway and potentially increase the expression of N-twist due to the complex cross-talk between survival pathways and differentiation signals.

(±)-Bay K 8644

71145-03-4sc-203324
sc-203324A
sc-203324B
1 mg
5 mg
50 mg
$84.00
$196.00
$817.00
(0)

Bay K8644 is a calcium channel agonist, which can increase intracellular calcium levels, potentially leading to signaling events that enhance N-twist expression.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

This inhibitor of Rho-associated protein kinase (ROCK) can lead to alterations in cytoskeletal dynamics, which can impact gene expression including the upregulation of N-twist.