N-twist Inhibitors
N-twist inhibitors refers to a distinct chemical class characterized by its unique molecular structure and functional properties. These inhibitors are designed to modulate specific biochemical pathways by targeting the N-twist motif, a structural element found in various biological molecules. The N-twist motif plays a crucial role in the conformational dynamics of certain biomolecules, particularly proteins and nucleic acids, influencing their three-dimensional shapes and functional activities.
The molecular architecture of N-twist inhibitors is intricately designed to interact with the N-twist motif through precise binding interactions. These inhibitors often exhibit a high degree of selectivity, recognizing and binding specifically to the target N-twist motif without interfering with unrelated molecular structures. The development of N-twist inhibitors involves a thorough understanding of the structural and dynamic aspects of the target biomolecule, enabling researchers to design molecules with optimal binding affinity and specificity. As a result, N-twist inhibitors represent a promising class of compounds for manipulating biological processes at the molecular level, offering insights into the fundamental mechanisms governing cellular functions. Ongoing research in this field aims to elucidate the diverse applications of N-twist inhibitors in modulating various biological pathways, paving the way for potential advancements in molecular biology and biochemistry.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine is a Hedgehog signaling pathway inhibitor. By inhibiting Smoothened (SMO), cyclopamine can reduce the expression of genes downstream of the Hedgehog pathway, including N-twist, which is upregulated by this pathway in certain contexts. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it prevents the activation of AKT, leading to reduced nuclear localization of β-catenin, which can regulate N-twist expression as part of the Wnt/β-catenin signaling pathway. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. It disrupts the actin cytoskeleton organization and cell motility. Since N-twist is associated with epithelial-mesenchymal transition (EMT), inhibiting ROCK can lead to stabilization of the epithelial phenotype, thus reducing N-twist activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a TGF-β receptor inhibitor. By blocking TGF-β signaling, it can inhibit the EMT process. This results in decreased N-twist expression, which is a key mediator of EMT induced by TGF-β. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a gamma-secretase inhibitor, which inhibits Notch signaling. Notch pathway can induce the expression of N-twist; hence, blocking Notch signaling with DAPT can reduce N-twist levels. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor. By inhibiting MEK, it prevents the activation of ERK, which is part of the MAPK pathway that can lead to the expression of N-twist. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. By inhibiting JNK signaling, this compound can reduce AP-1 activity, which has been implicated in the regulation of N-twist during cellular stress responses. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
SU5402 is an FGFR inhibitor. FGFR signaling can lead to the activation of several pathways, including MAPK, which can induce N-twist expression. Inhibiting FGFR can, therefore, reduce the expression of N-twist. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a compound known to inhibit multiple signaling pathways, including NF-κB, which is involved in the regulation of N-twist expression during inflammatory responses. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
AZD0530 is a Src kinase inhibitor. Src kinase activity has been linked to the regulation of EMT and N-twist expression. Inhibiting Src can result in reduced N-twist activity. | ||||||