Myo-inositol oxygenase Activators
The chemical class termed Myo-inositol oxygenase (MIOX) Activators constitutes a distinctive group of compounds capable of influencing cellular processes through the activation of the myo-inositol oxygenase enzyme. Myo-inositol oxygenase plays a crucial role in the catabolism of myo-inositol, a key component of cell signaling pathways and membrane structure. The activation of MIOX by these compounds involves specific molecular interactions, where activators engage with the enzyme, inducing conformational changes that enhance its catalytic efficiency in the oxidation of myo-inositol to D-glucuronic acid. Advanced structural techniques, including X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy, are pivotal in unraveling the intricate details of the binding sites and the induced structural alterations within the MIOX-activator complex. These studies provide a high-resolution snapshot of the molecular interactions, shedding light on how activators influence the enzyme's active site and catalytic machinery.
The methods employed by Myo-inositol oxygenase Activators are intricately linked to their structural features. These activators typically harbor specific chemical motifs that facilitate selective binding to MIOX, promoting a targeted and efficient response. The specificity of this interaction is essential for the precise modulation of MIOX's activity in myo-inositol catabolism. Structural studies, such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy, can be employed to unravel the details of the binding sites and conformational alterations induced by Myo-inositol oxygenase Activators. Understanding these molecular intricacies not only enhances our knowledge of MIOX activation but also contributes to a broader understanding of cellular processes related to inositol metabolism and its regulatory mechanisms. In summary, the elucidation of these molecular methods provides valuable insights into the intricate mechanisms through which Myo-inositol oxygenase Activators can influence cellular processes at the enzymatic level, particularly in the context of myo-inositol catabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent could induce hypomethylation of the MIOX gene promoter, which might lead to its decreased transcription and subsequent downregulation of MIOX protein expression. | ||||||
myo-Inositol | 87-89-8 | sc-202714 sc-202714A sc-202714B sc-202714C | 100 g 250 g 1 kg 5 kg | $80.00 $151.00 $275.00 $837.00 | ||
Myo-Inositol is the substrate for MIOX and its availability can influence MIOX activity. Increasing myo-inositol levels could potentially increase MIOX activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a specific inhibitor of histone deacetylase, Trichostatin A could relax the chromatin structure at the MIOX gene, leading to a reduction in its transcription efficiency. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose can influence myo-inositol levels and thus potentially impact MIOX indirectly. In the polyol pathway, glucose is converted to sorbitol, which can subsequently be converted to myo-inositol. | ||||||
D-(−)-Fructose | 57-48-7 | sc-221456 sc-221456A sc-221456B | 100 g 500 g 5 kg | $41.00 $91.00 $166.00 | 3 | |
Fructose, like glucose, can also affect myo-inositol levels through the polyol pathway and thus could indirectly influence MIOX activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might bind to retinoid receptors that then bind to the MIOX gene promoter, leading to a decrease in MIOX transcription due to altered receptor-mediated transcriptional repression. | ||||||
D-Sorbitol | 50-70-4 | sc-203278A sc-203278 | 100 g 1 kg | $29.00 $69.00 | ||
Sorbitol is a precursor of myo-inositol in the polyol pathway. Increasing sorbitol availability could potentially increase MIOX activity by raising myo-inositol levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may inhibit NF-κB pathway activation, resulting in decreased transcriptional activation of the MIOX gene and subsequent lower levels of MIOX expression. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a coenzyme involved in many redox reactions, including those in the polyol pathway that generates myo-inositol. NAD+ availability could indirectly influence MIOX activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could activate SIRT1, leading to deacetylation of histones associated with the MIOX gene, thereby resulting in tighter chromatin and reduced transcription of the MIOX gene. | ||||||