Myo-inositol oxygenase Antibody (E-11): sc-376080

Myo-inositol oxygenase Antibody (E-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Myo-inositol oxygenase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Myo-inositol oxygenase antibody (E-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Myo-inositol oxygenase (MIOX), also known as ALDRL6, is a renal-specific enzyme belonging to the Aldo-keto reductase family, playing a crucial role in the metabolism of Myo-inositol. MIOX catalyzes the oxidative cleavage of Myo-inositol and its epimer, D-chiro inositol, into D-glucuronate, marking the first committed step in the Myo-inositol metabolic pathway. This enzymatic activity is vital for maintaining cellular signaling and osmoregulation, particularly in renal tissues, where MIOX is predominantly expressed. MIOX function is particularly important in the context of diabetes, as alterations in Myo-inositol metabolism have been linked to diabetic nephropathy, highlighting MIOX potential as a therapeutic target. Myo-inositol oxygenase (E-11) monoclonal antibody is an essential tool for researchers investigating the role of MIOX in various physiological and pathological processes.

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Myo-inositol oxygenase Antibody (E-11) References:

1. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney.  |  Arner, RJ., et al. 2004. Biochem Biophys Res Commun. 324: 1386-92. PMID: 15504367
2. Expression of myo-inositol oxygenase in tissues susceptible to diabetic complications.  |  Arner, RJ., et al. 2006. Biochem Biophys Res Commun. 339: 816-20. PMID: 16332355
3. Structural and biophysical characterization of human myo-inositol oxygenase.  |  Thorsell, AG., et al. 2008. J Biol Chem. 283: 15209-16. PMID: 18364358
4. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.  |  Yang, B., et al. 2010. J Diabetes Complications. 24: 404-8. PMID: 19896870
5. Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury.  |  Gaut, JP., et al. 2014. Clin Chem. 60: 747-57. PMID: 24486646
6. Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.  |  Tominaga, T., et al. 2016. J Biol Chem. 291: 1348-67. PMID: 26578517
7. High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.  |  Sharma, I., et al. 2017. Am J Pathol. 187: 724-739. PMID: 28208054
8. Urinary myo-inositol is associated with the clinical outcome in focal segmental glomerulosclerosis.  |  An, JN., et al. 2019. Sci Rep. 9: 14707. PMID: 31605028
9. Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus.  |  Kısa, B., et al. 2022. Arch Physiol Biochem. 128: 910-913. PMID: 32191130
10. Serum myo-inositol oxygenase levels at hospital discharge predict progression to chronic kidney disease in community-acquired acute kidney injury.  |  Kakkanattu, TJ., et al. 2022. Sci Rep. 12: 13225. PMID: 35918463
11. Comparison of serum Kim-1 and Miox levels in patients that underwent percutaneous nephrolithotomy and flexible ureterorenoscopy.  |  Altun, A., et al. 2023. Urologia. 90: 335-341. PMID: 36062576

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myo-inositol oxygenase Antibody (E-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Myo-inositol oxygenase Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myo-inositol oxygenase Antibody (E-11) Specifications

Alternate Product Name: Myo-inositol oxygenase

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 2-29

Epitope Target: Myo-inositol oxygenase

Epitope Species: human

Product Reactivity/Detection: Myo-inositol oxygenase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Myo-inositol oxygenase Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin