MUP Inhibitors
Major urinary proteins (MUPs) are a family of small, highly conserved proteins predominantly found in the urine of rodents, although they are also present in other bodily fluids and tissues. MUPs serve multiple biological functions, including the transport and stabilization of volatile pheromonal cues, regulation of individual and social behaviors, and modulating the immune response. These proteins bind small volatile compounds with high specificity and release them slowly over time, a mechanism that is crucial for chemical communication in the animal kingdom. The slow release of pheromones mediated by MUPs plays a vital role in territorial marking, reproductive status signaling, and the establishment of social hierarchies. Additionally, the high level of genetic polymorphism observed in the MUP gene family contributes to individual-specific scent profiles, facilitating individual recognition and promoting genetic diversity within populations.
The inhibition of MUP function does not follow the typical pharmacological inhibition pathways seen with enzymes or receptors, given their role in binding and releasing volatile compounds rather than catalyzing biochemical reactions. However, theoretical mechanisms of inhibition could involve altering the binding affinity of MUPs for their ligands or interfering with the protein's ability to be secreted into urine and other fluids. For example, modifications to the protein structure through genetic mutation or the binding of non-pheromonal ligands with higher affinity than the natural pheromone substrates could reduce MUP's capacity to bind and release pheromonal cues effectively. Additionally, changes in the expression levels of MUPs, whether through genetic regulation or environmental factors, could also impact their biological function by altering the concentration of MUPs available for pheromone binding and transport. Such inhibition would disrupt the pheromonal communication system, affecting behaviors related to reproduction, territoriality, and social interactions.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan inhibits enoyl-acyl carrier protein reductase, a key enzyme in bacterial fatty acid synthesis. MUP is involved in lipid metabolism, and Triclosan's action disrupts fatty acid biosynthesis, leading to altered lipid composition within cells. This disruption can impact MUP-mediated lipid binding and signaling, ultimately inhibiting its function in cellular processes related to lipid metabolism. | ||||||
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $52.00 | 7 | |
THL is a lipase inhibitor that blocks the activity of pancreatic lipase. MUP is implicated in lipid metabolism, and Orlistat's inhibition of lipase activity indirectly affects MUP by altering lipid digestion and absorption. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin inhibits fatty acid synthase, a key enzyme in de novo fatty acid synthesis. MUP is involved in lipid metabolism, and Cerulenin's action disrupts fatty acid biosynthesis, leading to altered lipid composition within cells. This disruption can impact MUP-mediated lipid binding and signaling, ultimately inhibiting its function in cellular processes related to lipid metabolism. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662 is a selective inhibitor of peroxisome proliferator-activated receptor gamma (PPARγ). MUP is associated with PPARγ-mediated signaling pathways. GW9662's inhibition of PPARγ indirectly modulates MUP by disrupting downstream signaling. The altered transcriptional regulation and intracellular dynamics can lead to changes in MUP expression and function, influencing cellular processes related to lipid metabolism and PPARγ signaling. | ||||||
TOFA (5-(Tetradecyloxy)-2-furoic acid) | 54857-86-2 | sc-200653 sc-200653A | 10 mg 50 mg | $97.00 $374.00 | 15 | |
TOFA inhibits acetyl-CoA carboxylase, a key enzyme in fatty acid synthesis. MUP is involved in lipid metabolism, and TOFA's action disrupts fatty acid biosynthesis, leading to altered lipid composition within cells. This disruption can impact MUP-mediated lipid binding and signaling, ultimately inhibiting its function in cellular processes related to lipid metabolism. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Etomoxir inhibits carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in fatty acid oxidation. MUP is implicated in lipid metabolism, and Etomoxir's inhibition of CPT-1 disrupts fatty acid oxidation, leading to altered lipid composition within cells. This disruption can impact MUP-mediated lipid binding and signaling, ultimately inhibiting its function in cellular processes related to lipid metabolism. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that competitively inhibits glucose metabolism. MUP is associated with cellular responses to nutrient availability. 2-Deoxy-D-glucose's inhibition of glucose metabolism indirectly affects MUP by disrupting energy homeostasis. The resulting changes in nutrient availability can impact MUP-mediated responses to metabolic stress, influencing cellular processes related to energy metabolism and lipid signaling. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), a key regulator of energy metabolism. MUP is implicated in cellular responses to energy stress. AICAR-induced AMPK activation indirectly modulates MUP by altering energy-sensing pathways. The resulting changes in AMPK activity can influence MUP-mediated responses to metabolic stress and energy homeostasis, impacting cellular processes related to lipid metabolism and AMPK signaling. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor involved in lipid metabolism. MUP is associated with PPARα-mediated signaling pathways. Fenofibrate-induced PPARα activation enhances MUP function by influencing its interactions with signaling components, leading to altered cellular responses to lipid metabolism and PPARα signaling. | ||||||
Trimetazidine Dihydrochloride | 13171-25-0 | sc-220334 | 10 mg | $213.00 | ||
Trimetazidine inhibits 3-ketoacyl-CoA thiolase, a key enzyme in fatty acid oxidation. MUP is implicated in lipid metabolism, and Trimetazidine's inhibition of fatty acid oxidation disrupts energy homeostasis, leading to altered lipid composition within cells. This disruption can impact MUP-mediated lipid binding and signaling, ultimately inhibiting its function in cellular processes related to lipid metabolism. | ||||||