Molecular structure of Lipase Inhibitor, THL, CAS Number: 96829-58-2
Lipase Inhibitor, THL (CAS 96829-58-2)
See product citations (7)
Alternate Names:
(−)-Tetrahydrolipstatin; Orlistat
Application:
Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, and an activator of caspase-3.
CAS Number:
96829-58-2
Purity:
≥98%
Molecular Weight:
495.7
Molecular Formula:
C29H53NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that may act to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of Lipase Inhibitor, THL is phospholipase A2, which is not affected by Lipase Inhibitor, THL. Mechanistic studies suggest that Lipase Inhibitor, THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually Lipase Inhibitor, THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLalpha). Lipase Inhibitor, THL also activates caspase-3.
Lipase Inhibitor, THL (CAS 96829-58-2) References
- Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine. | Sternby, B., et al. 2002. Clin Nutr. 21: 395-402. PMID: 12381337
- Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. | Kridel, SJ., et al. 2004. Cancer Res. 64: 2070-5. PMID: 15026345
- A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. | Knowles, LM., et al. 2004. J Biol Chem. 279: 30540-5. PMID: 15138278
- Fate and uptake of pharmaceuticals in soil-earthworm systems. | Carter, LJ., et al. 2014. Environ Sci Technol. 48: 5955-63. PMID: 24762061
- Effects of soil properties on the uptake of pharmaceuticals into earthworms. | Carter, LJ., et al. 2016. Environ Pollut. 213: 922-931. PMID: 27049789
- Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan. | Theis, T., et al. 2018. Mol Neurobiol. 55: 8203-8215. PMID: 29520715
- Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. | Xiao, L., et al. 2018. Elife. 7: PMID: 29676731
- TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy. | Li, L., et al. 2019. Cell Metab. 29: 103-123.e5. PMID: 30344014
- EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma. | Shi, X., et al. 2020. Nucleic Acids Res. 48: 11434-11451. PMID: 33080033
- N-linoleyltyrosine ameliorates high-fat diet-induced obesity in C57BL/6 mice via cannabinoid receptor regulation. | Yang, ZY., et al. 2022. Front Endocrinol (Lausanne). 13: 938527. PMID: 36111301
- Anticancer Activity of Nano-formulated Orlistat-Dopamine Conjugates Through Self-Assembly. | Chen, S. and Liang, JF. 2023. Bioconjug Chem. 34: 581-593. PMID: 36802542
- Exploring the binding effects and inhibiting mechanism of hyperoside to lipase using multi-spectroscopic approaches, isothermal titration calorimetry, inhibition kinetics and molecular dynamics. | Zeng, Z., et al. 2023. RSC Adv. 13: 6507-6517. PMID: 36845588
- Artemisia annua L. (Sweet wormwood) leaf extract attenuates high-fat diet-induced testicular dysfunctions and improves spermatogenesis in obese rats. | El-Sawy, SA., et al. 2023. J Ethnopharmacol. 313: 116528. PMID: 37127141
- Anti-Inflammatory Effect of Ethanolic Extract from Tabebuia rosea (Bertol.) DC., Quercetin, and Anti-Obesity Drugs in Adipose Tissue in Wistar Rats with Diet-Induced Obesity. | Barrios-Nolasco, A., et al. 2023. Molecules. 28: PMID: 37175211
- Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat). | Lookene, A., et al. 1994. Eur J Biochem. 222: 395-403. PMID: 8020477
Inhibitor of:
2900097C17Rik, 5330437I02Rik, 9430007A20Rik, AADACL1, AADACL3, AADACL4, AASDHPPT, ABHD12B, ABHD13, ABHD14B, ABHD15, ABHD2, ABHD3, ABHD6, ABHD8, ABHD9, ACOT5, ACSS3, ACSVL3, ACSVL6, Adipogenin, Afamin, AI747699, AMAC1L2, Angptl5, apoA-IV, apoB48R, ATGL, AWAT1, BBS10, CEL, Ces1a, Ces1d, Ces3b, Cholesterol Esterase, CIDE-C, colipase, CROT, CYB5R1, CYP27A1, DAGL, DAGLα, DAGLβ, DDHD1, DDHD2, DECR2, DGAT2L3, DGAT2L4, DGAT2L6, DNAH17, DSCD75, EG13909, EG329055, EG432995, EG624219, EG666803, EG668114, ELOVL (ELOngation of Very Long chain fatty acids), emerin, Endothelial Lipase, FA2H, FABP12, FADS6, FAM57B, FAR1, FAR2, Fat, Fatty Acid Synthase, FIT1, FSBA, Gα olf, Gastric Lipase, Gm1679, Gm436, GRAMD1A, GS2-like, Hepatic Lipase, HSDL2, HSL, ILDR1, KIAA0562, LENG4, LIPH, LIPK, LIPN, Lmf1, Lmf2, LPAAT-ε, LPCAT1, LPD lipase, LPGAT1, LPL, LRP2BP, LYPLA1, MBOAT2, MCAT, MDGI, MGAT2, mMGL, MULK, MUP, NAPE-PLD, Pancreatic Lipase, PE, Plb3, PLRP2, PLRP3, PPAPDC3, PSS2 (PTDSS2; phosphatidylserine synthase 2), SEC14L3, SEC14L4, SEC14L5, Seipin, SgK223, STARD, StARD10, SUDD, TAG, TGH-2, THEM5, TMEM18, TMEM68, TSGA2, ZAG, ZDHHC21, ZDHHC5, and ZP3.Activator of:
AADACL2, ACBP, AI747699, apoC-II, ARV1, C20orf79, caspase-3, Ces3b, FAIM2, Lmf2, LPPR3, P76, Pancreatic Lipase, PLBD1, PLRP1, REEP6, SCP-2, SCP2D1, SDR16C6, TM6SF2, TMEM164, and TMEM35.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lipase Inhibitor, THL, 50 mg | sc-203108 | 50 mg | $51.00 |