Molecular structure of GW 9662, CAS Number: 22978-25-2
GW 9662 (CAS 22978-25-2)
See product citations (30)
Alternate Names:
2-chloro-5-nitrobenzanilide; 2-Chloro-5-nitro-N-phenylbenzamide
Application:
GW 9662 is a selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist
CAS Number:
22978-25-2
Purity:
>95%
Molecular Weight:
276.7
Molecular Formula:
C13H9ClN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW 9662 is a selective, irreversible, and effective peroxisome proliferator activated receptor-gamma (PPARgamma) antagonist. PPARgamma research demonstrates that GW 9662 covalently modifies Cys(285) and does not affect transcription of full-length PPARalpha and PPARdelta. GW 9662 may act to block Rosiglitazone (sc-202795)-mediated activation of PPARgamma, and improve growth inhibition induced by Rosiglitazone in breast tumor cell research. Additionally, reports indicate that GW 9662 blocks the protective activity of lipopolysaccharide, LPS, and acts as an agonist for the farnesoid X receptor (FXR) and pregnane X receptor (PXR) nuclear receptors.
GW 9662 (CAS 22978-25-2) References
- Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. | Huang, JT., et al. 1999. Nature. 400: 378-82. PMID: 10432118
- Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. | Leesnitzer, LM., et al. 2002. Biochemistry. 41: 6640-50. PMID: 12022867
- GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation. | Seargent, JM., et al. 2004. Br J Pharmacol. 143: 933-7. PMID: 15533890
- The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. | Collino, M., et al. 2005. Kidney Int. 68: 529-36. PMID: 16014029
- Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia. | Collin, M., et al. 2006. Crit Care Med. 34: 1131-8. PMID: 16484917
- Troglitazone reverses the multiple drug resistance phenotype in cancer cells. | Davies, GF., et al. 2009. Drug Des Devel Ther. 3: 79-88. PMID: 19920924
- PPARγ agonism attenuates cocaine cue reactivity. | Miller, WR., et al. 2018. Addict Biol. 23: 55-68. PMID: 27862692
- Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways. | Ma, ZG., et al. 2017. EBioMedicine. 18: 179-187. PMID: 28330809
- 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ. | Han, Q., et al. 2017. Oncotarget. 8: 42001-42006. PMID: 28410218
- Evidence of a PPARγ-mediated mechanism in the ability of Withania somnifera to attenuate tolerance to the antinociceptive effects of morphine. | Caputi, FF., et al. 2019. Pharmacol Res. 139: 422-430. PMID: 30503841
- PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway. | Li, Z., et al. 2022. Oxid Med Cell Longev. 2022: 1269747. PMID: 35136484
- GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease. | Baumann, A., et al. 2022. Metabolism. 133: 155233. PMID: 35654114
- KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling. | Li, F., et al. 2022. Cells. 11: PMID: 36359788
Inhibitor of:
AADACL4, ABCG8, ABHD1, ABHD15, ABHD5, Adipogenin, Angptl7, AP-2σ1, APM2, apoD, betaKlotho, C/EBP α, C/EBP ε, C1QTNF (C1q and TNF related), C20orf117, CEACAM1, ChREBP, COUP-TFI, CTRP6, CTRP7, Dppa5b, Dppa5c, EG329055, EG436008, EG436059, FAM159A, FIGLA, FNDC5, GP-39, GPD1, GPR142, GPR39, GPR6, Helios, Langerin, LCORL, LDLRAD1, LPAAT-ζ, LRP12, LYRM1, MDGI, MEF-2A, MEF-2D, METRNL, MUP, Myocyte enhancer factor (MEF2), Nidogen, NR5A2, Olfr477, Olfr479, Olfr585, Olfr608, Olfr609, Olfr61, Olr22, OR52E4, OR5D14, PAQR4, PAT2, PECR, Periostin, Peroxin 13, PGC-1β, PNPLA7, PRC, PSG5, resistin, resistin-like β, RNF157, SCGB1D4, SIM1, Sva, T2R5, TCP-10a, THEM5, Thyroglobulin, TMEM68, Tomm20l, TTC39B, V1RB1, and Vmn2r44.Activator of:
A-FABP, ACP6, Btnl6, CD36, CES3, D830030K20Rik, EG231736, EG384585, EG545802, FOXC1, FXR, Glut2, LI-cadherin, N-CoR, NP220, PEPCK-C, PXR, Rtl1, TG1019, THP, TLE2, and Vasorin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 9662, 5 mg | sc-202641 | 5 mg | $68.00 |