Date published: 2026-5-4

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Trimetazidine Dihydrochloride (CAS 13171-25-0)

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Alternate Names:
1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine Dihydrochloride; 1-(2,3,4-Trimethoxybenzyl)piperazine Dihydrochloride; Kyurinett; Vastarel F; Yoshimilon
Application:
Trimetazidine Dihydrochloride is an antianginal and coronary vasodilator
CAS Number:
13171-25-0
Purity:
≥99%
Molecular Weight:
339.26
Molecular Formula:
C14H22N2O32HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trimetazidine Dihydrochloride is a compound that has been the subject of various studies in the fields of cellular metabolism and cardiology research. Its primary mechanism involves the inhibition of long-chain 3-ketoacyl CoA thiolase (3-KAT), which shifts cellular energy metabolism from fatty acid oxidation to glucose oxidation. Research on Trimetazidine Dihydrochloride often centers on its effects on mitochondrial function and its ability to protect cells under conditions of ischemic stress. Studies may explore the compound′s impact on cardiac efficiency, especially under conditions of limited oxygen supply. Furthermore, Trimetazidine Dihydrochloride is used in research to understand its influence on the metabolism and function of other high-energy-demand tissues. The dihydrochloride salt form of Trimetazidine is relevant for its improved solubility in water, which is advantageous for in vitro experiments. Researchers may also investigate the compound′s role in the modulation of reactive oxygen species production within cells.


Trimetazidine Dihydrochloride (CAS 13171-25-0) References

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  2. Bioavailability studies on guar gum-based three-layer matrix tablets of trimetazidine dihydrochloride in human volunteers.  |  Krishnaiah, YS., et al. 2002. J Control Release. 83: 231-9. PMID: 12363449
  3. Determination of trimetazidine dihydrochloride in the presence of its acid-induced degradation products.  |  Bebawy, LI., et al. 2004. J AOAC Int. 87: 827-33. PMID: 15295875
  4. Sensitive determination of trimetazidine in spiked human plasma by HPLC with fluorescence detection after pre-column derivatization with 9-fluorenylmethyl chloroformate.  |  Khedr, A., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 856: 337-42. PMID: 17644495
  5. Computer-assisted optimization and validation of LC analysis of trimetazidine dihydrochloride and its impurities.  |  Medenica, MB., et al. 2008. J Chromatogr Sci. 46: 430-5. PMID: 18492354
  6. Formulation and evaluation of trimetazidine dihydrochloride extended release tablets by melt congealing method.  |  Javeer, SD., et al. 2010. Indian J Pharm Sci. 72: 704-9. PMID: 21969741
  7. Ultrasonic microdialysis coupled with capillary electrophoresis electrochemiluminescence study the interaction between trimetazidine dihydrochloride and human serum albumin.  |  Sun, S., et al. 2014. Anal Chim Acta. 851: 37-42. PMID: 25440662
  8. Stability-indicating determination of trimetazidine dihydrochloride inthe presence of two of its related substances using a direct GC/MS method.  |  Belal, TS., et al. 2014. J AOAC Int. 97: 1514-8. PMID: 25632428
  9. Feasibility of optimizing trimetazidine dihydrochloride release from controlled porosity osmotic pump tablets of directly compressed cores.  |  Habib, BA., et al. 2014. J Adv Res. 5: 347-56. PMID: 25685502
  10. Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.  |  Gül, F., et al. 2016. Kulak Burun Bogaz Ihtis Derg. 26: 114-7. PMID: 26890714
  11. In vitro dissolution and in vivo bioequivalence evaluation of two brands of trimetazidine tablets.  |  Helmy, SA. and Mansour, NO. 2014. Clin Pharmacol Drug Dev. 3: 139-43. PMID: 27128458
  12. Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study.  |  Kumral, TL., et al. 2016. Clin Exp Otorhinolaryngol. 9: 192-7. PMID: 27230273
  13. Comparison of high-performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for the determination of trimetazidine in pharmaceutical formulations.  |  Gackowski, M., et al. 2019. Acta Pharm. 69: 413-422. PMID: 31259733
  14. Preparation and Preliminary Evaluation of a Promising 99mTc-Labeled Isonitrile-Containing 6-Thia-Fatty Acid Derivative for Myocardial Metabolism Imaging.  |  Fang, Y., et al. 2023. J Med Chem. 66: 3953-3967. PMID: 36950862

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trimetazidine Dihydrochloride, 10 mg

sc-220334
10 mg
$213.00