Triclosan CAS: 3380-34-5
MF: C12H7Cl3O2
MW: 289.54
Triclosan is an inhibitor of fatty acid synthase.

Triclosan (CAS 3380-34-5)

Triclosan | CAS 3380-34-5 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-Chloro-2-(2,4-dichlorophenoxy)phenol; Irgasan; Triclosan
Application: Triclosan is an inhibitor of fatty acid synthase
CAS Number: 3380-34-5
Purity: ≥99%
Molecular Weight: 289.54
Molecular Formula: C12H7Cl3O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Triclosan is an inhibitor of fatty acid synthase which has demonstrated bacteriostatic, antiseptic, and preservative properties.


References

1. Black, J G., et al., 1975. Percutaneous absorption and metabolism of Irgasan DP300. Toxicology. 3(1): 33-47. PMID: 1121705

2. Lindström, Anton., et al., 2002. Occurrence and environmental behavior of the bactericide triclosan and its methyl derivative in surface waters and in wastewater. Environmental science & technology. 36(11): 2322-9. PMID: 12075785

Physical State :
Solid
Solubility :
Soluble in water (12 mg/ml at 20° C), methanol, chloroform, DMSO, and acetone.
Storage :
Store at 4° C
Melting Point :
56.4° C
Boiling Point :
280-290° C (dec.) at 760 mmHg
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Enoyl-ACP reductase: IC50 = 0.48 nM (Plasmodium falciparum); Enoyl-acyl-carrier protein reductase: IC50 = 0.48 nM (Plasmodium falciparum); Enoyl-acyl carrier reductase: IC50 = 15 nM (Toxoplasma gondii); Enoyl-[acyl-carrier-protein] reductase [NADPH]: IC50 = 59 nM (Staphylococcus aureus); Enoyl-ACP reductase: IC50 = 200 nM (Plasmodium falciparum)
Ki Data :
Enoyl-acyl-carrier protein reductase: Ki= 0.0019 nM; Carbonyl reductase 1: Ki= 60 nM (human); Enoyl-[acyl-carrier-protein] reductase: Ki= 200 nM
pK Values :
pKa: 7.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KO1100000
PubChem CID :
Merck Index :
14: 9657
MDL Number :
MFCD00800992
EC Number :
222-182-2
Beilstein Registry :
2057142
SMILES :
C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kim Kim, SA. et al. (PubMed 26374612) invesitgated the bactericidal effects of Triclosan in soap both in vitro and in vivo. Antibacterial soap containing Triclosan (0.3%) was no more effective than plain soap at reducing bacterial contamination when used under 'real-life' conditions. -SCBT Publication Review
Date published: 2015-06-11
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