Molecular structure of Triclosan, CAS Number: 3380-34-5
Triclosan (CAS 3380-34-5)
Alternate Names:
5-Chloro-2-(2,4-dichlorophenoxy)phenol; Irgasan; Triclosan
Application:
Triclosan is an inhibitor of fatty acid synthase
CAS Number:
3380-34-5
Purity:
≥98%
Molecular Weight:
289.54
Molecular Formula:
C12H7Cl3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Triclosan is an inhibitor of fatty acid synthase which has demonstrated bacteriostatic, antiseptic, and preservative properties. Triclosan, a synthetic compound structurally resembling natural phenols, possesses a wide range of activity against both Gram-positive and Gram-negative bacteria, as well as certain fungi. Its mechanism of action involves inhibiting the growth of bacteria and fungi. Triclosan achieves this by interfering with cell wall formation and hindering the production of enzymes essential for cell metabolism. Furthermore, it disrupts the integrity of the cell membrane, ultimately resulting in cell death.
Triclosan (CAS 3380-34-5) References
- Percutaneous absorption and metabolism of Irgasan DP300. | Black, JG., et al. 1975. Toxicology. 3: 33-47. PMID: 1121705
- Triclosan: a widely used biocide and its link to antibiotics. | Schweizer, HP. 2001. FEMS Microbiol Lett. 202: 1-7. PMID: 11506900
- Occurrence and environmental behavior of the bactericide triclosan and its methyl derivative in surface waters and in wastewater. | Lindström, A., et al. 2002. Environ Sci Technol. 36: 2322-9. PMID: 12075785
- Triclosan: a shot in the arm for antimalarial chemotherapy. | Rao, SP., et al. 2003. Mol Cell Biochem. 253: 55-63. PMID: 14619956
- Whither triclosan? | Russell, AD. 2004. J Antimicrob Chemother. 53: 693-5. PMID: 15073159
- Triclosan: environmental exposure, toxicity and mechanisms of action. | Dann, AB. and Hontela, A. 2011. J Appl Toxicol. 31: 285-311. PMID: 21462230
- Triclosan: current status, occurrence, environmental risks and bioaccumulation potential. | Dhillon, GS., et al. 2015. Int J Environ Res Public Health. 12: 5657-84. PMID: 26006133
- Triclosan exposure, transformation, and human health effects. | Weatherly, LM. and Gosse, JA. 2017. J Toxicol Environ Health B Crit Rev. 20: 447-469. PMID: 29182464
- Triclosan and its derivatives as antimycobacterial active agents. | Vosátka, R., et al. 2018. Eur J Pharm Sci. 114: 318-331. PMID: 29277667
- Triclosan: An Update on Biochemical and Molecular Mechanisms. | Alfhili, MA. and Lee, MH. 2019. Oxid Med Cell Longev. 2019: 1607304. PMID: 31191794
- Triclosan: antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health. | Shrestha, P., et al. 2020. J Environ Sci Health C Toxicol Carcinog. 38: 245-268. PMID: 32955413
- Triclosan uptake and transformation by the green algae Euglena gracilis strain Z. | Lam, KY., et al. 2022. Sci Total Environ. 833: 155232. PMID: 35427625
- Preimplantation triclosan exposure alters uterine receptivity through affecting tight junction protein†. | Dong, G., et al. 2022. Biol Reprod. 107: 349-357. PMID: 35554491
- Triclosan is the Predominant Antibacterial Compound in Ontario Sewage Sludge. | Barrett, H., et al. 2022. Environ Sci Technol. 56: 14923-14936. PMID: 35594374
- Triclosan and related compounds in the environment: Recent updates on sources, fates, distribution, analytical extraction, analysis, and removal techniques. | Sun, C., et al. 2023. Sci Total Environ. 870: 161885. PMID: 36731573
Inhibitor of:
β-ketoacyl synthase, 5330437I02Rik, AASDHPPT, Abp δ, ACOT5, ACOX2, ACSM5, ACSS3, ACY1L2, AKR1C21, AMDHD1, apoD, Barhl1, BCDO2, Bordetella pertussis, BRCC2, Calbindin D9K, Carbonyl reductase 1, Ces3b, CHST1, CYP2A12, CYP2A5, Cyp2c54, CYP2J7, CYP2J8, Dbil5, E. coli K99, EFO2, EG436008, Enterobacter cloacae, Eppin, Fatty Acid Synthase, FOXE2, FSBA, GAL3ST1, GalNAc4S-6ST, GalNAc4ST-1, Gm766, GNPAT, HACL1, HADHB, HS6ST2, KNAT2, KRTAP16-5, LEKTI, Lipid A, MCAT, MUP, N-myristoyltransferase 2, NKPD1, ODAM, Olfr354, OR10A7, PAT2, PE, Phosphotransacetylase, PHYHD1, Pira7, PTPMT1, pyridoxal kinase, Rshl2a, RV3134 Dormancy Regulon, S100A7A, SCD2, SMCP, SPACA3, SPACA7, SPINDLY, SULT1C1, SULT1C2, SULT1C3, SULT1C4, SULT1D1, SULT2A3, SULT2A6, SULT2A7, SULT2B1, SULT2B10, SULT6B1, TMPRSS11C, TPST-2, and ZP3.Activator of:
β-defensin 108C, β-defensin 113, β-defensin 3B, β-defensin 41, 4732415M23Rik, Abp δ, Abp ε, c-Erb-A β-1, Ces3b, COX6b1, Cyp3a59, CYP4A, CYP4A14, Cyp4f37, Cyp4f39, DCAR, Dmrtc1b, Dynlt1d, H2-Q10, KLHDC7A, Lipocalin-5, LOC100039899, LYZL1, MUP18, PATE3, Pate4, progonadoliberin I, ROPN1B, RXR beta, Skint7, TR4, V1RB2, VASA, and VCX-C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triclosan, 10 g | sc-220326 | 10 g | $138.00 | |||
Triclosan, 100 g | sc-220326A | 100 g | $400.00 |