MT-MMP-6 Activators
The MT-MMP-6 Activators chemical class is a collection of compounds that indirectly influence the activity of Membrane-type matrix metalloproteinase 6 (MT-MMP-6), an enzyme integral to the remodeling of the extracellular matrix. This diverse group includes various chemicals that, while not directly interacting with MT-MMP-6, affect its expression, activation, or enzymatic activity through modulation of cellular pathways and the extracellular environment. Key members of this class, like Phorbol 12-myristate 13-acetate (PMA), exert their effect by activating Protein Kinase C (PKC), a pathway that can lead to increased expression and activity of MT-MMP-6. Tetracyclines like Doxycycline, known for their ability to modulate matrix metalloproteinase (MMP) activities, are also included, given their potential indirect effects on MT-MMP-6 dynamics.
Additionally, this class encompasses compounds that impact the bioavailability of essential cofactors for MT-MMP-6 activity. Calcium and zinc chlorides, providing crucial ions, are fundamental for the catalytic action of many MMPs, including MT-MMP-6. Hydroxamic acid derivatives, known for their interactions with MMPs, may also influence MT-MMP-6, albeit in a less direct manner. Interestingly, some members of this class, such as GM6001 and Batimastat, are broad-spectrum MMP inhibitors but might have paradoxical effects on MT-MMP-6 under certain conditions, possibly enhancing its activity. This complex interplay highlights the nuanced mechanisms through which these compounds influence MT-MMP-6, illustrating the intricate balance of enzyme regulation within the extracellular matrix. The MT-MMP-6 Activators class, therefore, represents a crucial area of study in understanding the molecular regulation of extracellular matrix remodeling, shedding light on the diverse range of chemical agents that can indirectly modulate the activity of this key enzyme.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is a synthetic inhibitor of broad-spectrum matrix metalloproteinases (MMPs). By inhibiting other MMPs, Batimastat may lead to a compensatory increase in MT-MMP 6 activity as the tissue remodeling process is tightly regulated and compensatory mechanisms can enhance the activity of specific MMPs when others are inhibited. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Similar to Batimastat, Marimastat is an MMP inhibitor with a broad range. Inhibition of certain MMPs can result in upregulation or increased activity of other MMPs, including MT-MMP 6, as part of the tissue remodeling homeostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC), which can enhance MT-MMP-6 expression and activity. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
GM6001 is another broad MMP inhibitor. By blocking the activity of various MMPs, it could indirectly increase the functional activity of MT-MMP 6 as the cell may compensate for the inhibited proteolytic activity by upregulating other proteases, including MT-MMP 6. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a selective inhibitor of gelatinase MMPs. By specifically targeting gelatinases, it may indirectly enhance MT-MMP 6 activity by shifting the balance of proteolytic activity within the extracellular matrix toward membrane-type MMPs including MT-MMP 6. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline can modulate MMP expression, potentially influencing MT-MMP-6 activity. | ||||||
PD166793 | 199850-67-4 | sc-202709 | 5 mg | $150.00 | 6 | |
PD166793 is an MMP inhibitor that, by attenuating the activity of certain MMPs, could lead to enhanced MT-MMP 6 activity as the cellular matrix remodeling system seeks to maintain homeostasis. | ||||||
NSC 405020 | 7497-07-6 | sc-477738 | 10 mg | $105.00 | ||
NSC 405020 is a selective antagonist of MT1-MMP, which may indirectly increase MT-MMP 6 activity by causing the cell to enhance the activity of other related MMPs, including MT-MMP 6, to compensate for the inhibition of MT1-MMP. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
ARP 100 is an MMP inhibitor that could lead to an increase in MT-MMP 6 activity by indirect compensatory mechanisms within the cell′s protease network, specifically within the matrix remodeling pathways. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline, a tetracycline antibiotic, is known to modulate MMP activity and may indirectly affect MT-MMP- | ||||||