Molecular structure of PD173074, CAS Number: 219580-11-7
PD173074 (CAS 219580-11-7)
See product citations (16)
Alternate Names:
FGF/VEGF Receptor Tyrosine Kinase Inhibitor; N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea
Application:
PD173074 is Potent inhibitor of FGF and VEGF (Flt/Flk) receptors
CAS Number:
219580-11-7
Purity:
≥98%
Molecular Weight:
523.67
Molecular Formula:
C28H41N7O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 is a cell-permeable pyridopyrimidine compound that may act to act as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors {IC50 = 21.5 nM for Flg (FGFR1)}. It has been used to inhibit PDGFR and c-Src only at much higher concentration (IC50 = 17.6 muM, 19.8 muM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 muM. It has also been shown to inhibit the autophosphorylation of endogenous Flg (FGFR1, IC50
PD173074 (CAS 219580-11-7) References
- The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. | Skaper, SD., et al. 2000. J Neurochem. 75: 1520-7. PMID: 10987832
- Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. | Trudel, S., et al. 2004. Blood. 103: 3521-8. PMID: 14715624
- Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins. | Koziczak, M., et al. 2004. Oncogene. 23: 3501-8. PMID: 15116089
- Fibroblast growth factor receptors as molecular targets in thyroid carcinoma. | St Bernard, R., et al. 2005. Endocrinology. 146: 1145-53. PMID: 15564323
- Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. | Zaragosi, LE., et al. 2006. Stem Cells. 24: 2412-9. PMID: 16840552
- A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. | Stavridis, MP., et al. 2007. Development. 134: 2889-94. PMID: 17660197
- FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. | Kunath, T., et al. 2007. Development. 134: 2895-902. PMID: 17660198
- PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. | Patel, A., et al. 2013. Cancer Chemother Pharmacol. 72: 189-99. PMID: 23673445
- Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis. | Ye, T., et al. 2014. Breast Cancer Res Treat. 143: 435-46. PMID: 24398778
- Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression. | Zheng, Y., et al. 2015. J Cardiovasc Pharmacol. 66: 504-14. PMID: 26535780
- PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. | Anreddy, N., et al. 2014. Acta Pharm Sin B. 4: 202-7. PMID: 26579384
- PD173074 blocks G1/S transition via CUL3-mediated ubiquitin protease in HepG2 and Hep3B cells. | Qiao, C., et al. 2020. PLoS One. 15: e0234708. PMID: 32555680
- Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. | Mohammadi, M., et al. 1998. EMBO J. 17: 5896-904. PMID: 9774334
Inhibitor of:
β-1,3-Gal-T5, 1110059E24Rik, 1700001F09Rik, 1700009P17Rik, 1700010D01Rik, 1700010L13Rik, 1700011A15Rik, 1700011F14Rik, 1700011I03Rik, 1700022C21Rik, 1700022P22Rik, 1700023C21Rik, 1700027N10Rik, 1700029I01Rik, 1810020G14Rik, 1810029B16Rik, 2010305A19Rik, 2510006D16Rik, 2610528A11Rik, 2700089E24Rik, 3110037I16Rik, 3222402P14Rik, 4930546H06Rik, 4930570C03Rik, 4932411E22Rik, 4932432K03Rik, 4933403F05Rik, 4933426M11Rik, 4933428G09Rik, 5133401N09Rik, 5730437N04Rik, 5830403L16Rik, 5830404H04Rik, 5830457O10Rik, 6330416L07Rik, 6330503C03Rik, ABTB2, ACCSL, ACPT, ADO, Ang-4, ANKRD15, ANKRD38, ANKRD45, ATRNL1, AWP1, AZI1, BAHCC1, BAIAP2L1, BC031441, BC033915, BC037034, BC038925, BC046404, BC051019, BC052328, BC053749, BC056474, BC080695, BCAR3, Bcl11a, bFGF, BTBD7, BXDC2, C/EBP ε, C11orf24, C11orf61_BC024479, C12orf40, C12orf41, C12orf42, C14orf1_0610007P14Rik, C14orf159, C15orf59, C16orf73, C16orf82, C17orf28, C17orf80, C19orf21, C19orf44, C19orf56, C1orf187, C22orf34, C4orf37, C5orf22, C6orf26, C6orf57, C6orf62, C6orf70, C8orf31, C9orf47, C9orf50, CBWD7, CCDC106, CD133, CD96, CGREF1, CL-P1, CLEC-2E, Cnpy1, COL11A2, CPO, CRIP2, CXorf56, DPY19L1, DQX1, DSC1B, E230008N13Rik, EG668339, ELSPBP1, EMX (Empty Spiracles Homeobox), EYA1, FAM13b, FAM26D, FAM46A, FEM-3, Fer, FEZF1, FGF-2, FGF-8F, FGF-BP, FGF-BP3, FGFR-3, FHL-5, FIBP, Fibroblast Growth Factor (FGF), FIGNL1, Flg, Fliz1, FLJ39639, FLJ45513, Flk-1, FOG, FOXD4L1, FOXL1, Fragilis, FRRS1, FXRβ, GBX1, GFR-1, GFRαL, GLIPR1L3, GLTSCR1, Gm12, hemicentin-1, HEPN1, HESX1, HGK, HIVEP1, HoxA13, HoxC11, HoxC8, IAH1, IGFL3, Integrin α7, Integrin β6, IRGQ1, IRX1, IRX5, ISOC1, ITFG2, Laminin β-4, LENG9, LIN-45, LIT-1, LOC100041078, LOC100041215, LOC100041222, LOC100041228, LOC100041280, LOC100041317, LOC100041343, LOC100041358, LOC100041376, LOC100041388, LOC100041450, LOC130951, LOC144097_AI846148, LOC283904, LOC284009, LOC388284, LOC400553, LOC643714, LOC645722, LOC646014, LOC646043, LOC646960, LOC647176, LOC728149, LOC728478, LOC728520, LOC728756, LOC728804, LOC728896, LOC728991, LOC729104, LOC729464, LOC729791, LOC729895, LOC730151, LOC730230, LOC730270, LRRC6, LZP, MAB21L2, Maestro, MCCD1, MGC14376, MIER2, mMgl1, MOSPD2, MrgA9, MTERFD3, NALP4B, NG2, Nkx-6.3, Olfr598, Olfr599, Olfr6, Olfr60, Olfr600, Olfr601, Olfr604, Opalin, OR1D4, OR52E4, OTTMUSG00000011792, OTTMUSG00000012042, OTTMUSG00000019265, p120, p18SRP, PAGE-2B, PCDH1_Pcdh1, PERLD1, Plexin, plexin-B2, Podocan, PPIAL4, PPIAL4F, Prickle1, PROCA1, PSG5, PTH/PTHrP-R, PTN, Rab L3, RGD1562043, RIFF, robo1, RP24-142A19.3, SARP3, SBEM, SEMA3D, SEMA3E, SEMA6D, SGTB, Sidekick-2, SKT, SLC35C2, Slit2, SPATA1, SPEER-4A, SSXB2, TBC1D3H, TBX20, TCL-1B3a, TCP-10c, TEX2, TMEM196, TMEM245, TMEM46, TMEM98, TPBG, Trav3d-3, TSPYL1, Tyrosine Kinase, UNC5H3, V-ATPase C2, V1RE9, Vacuolar ATPase (V-ATPase; ATP6), VAX2, Vmn1r100, Vmn2r121, VRTN, WFIKKN, ZN-16, ZNF135, ZNF230, ZNF234, ZNF253, ZNF257, ZNF284L, ZNF285A, ZNF302, ZNF324B, ZNF333, ZNF383, ZNF452, ZNF592, ZNF613, ZNF615, ZNF616, ZNF652, and ZNRD1.Activator of:
β-FR, ATP1B3, BBS5, Bek, CCDC40, Delta-4, FGF-1, glypican-6, Hic-5, IFT20, Jagged, Lefty-1, Lefty-A, Lefty-B, MINK1, MT-MMP-6, Oct-3/4, PDE8A, PRAT4B_Cnpy4, PRX1, SHISA3, SHOX2A, Tenascin-X, VSX1, and YKL-39.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD173074, 1 mg | sc-202610 | 1 mg | $46.00 | |||
PD173074, 5 mg | sc-202610A | 5 mg | $140.00 | |||
PD173074, 50 mg | sc-202610B | 50 mg | $680.00 |