MS4A4D Inhibitors
Chemical inhibitors of MS4A4D function through various mechanisms to impede its activity by targeting signaling pathways that are crucial for its activation. Genistein operates by obstructing tyrosine kinase-dependent signaling pathways, which are essential for phosphorylation events that activate MS4A4D. Similarly, PP2 contributes to the inhibition by selectively preventing Src family kinases from phosphorylating their substrates; this action is vital as these kinases are requisite for the activation of several proteins, including MS4A4D. LY294002 and Wortmannin both serve as PI3K inhibitors and impede the PI3K/Akt signaling pathway. By inhibiting this pathway, these chemicals lead to a decrease in the activation of downstream proteins such as MS4A4D, which require this route for proper function. Furthermore, PD98059 and U0126, both MEK inhibitors, inhibit the MAPK/ERK pathway. Disrupting this pathway is instrumental in precluding the necessary phosphorylation events that would otherwise facilitate MS4A4D activity.
Additional compounds like SB203580, a p38 MAPK inhibitor, and SP600125, a JNK inhibitor, obstruct their respective MAPK pathways, thereby inhibiting the functional activation of MS4A4D. This effect arises because MS4A4D is contingent on the signaling mediated by these kinases for its activity. Rapamycin, an mTOR inhibitor, inhibits the mTOR signaling pathway; this pathway is a central conduit for various cellular processes, and its inhibition results in reduced activity of proteins potentially regulated by mTOR, including MS4A4D. Y-27632 acts as a ROCK inhibitor, impeding the Rho/ROCK pathway and, consequently, the activity of MS4A4D which may be regulated by this route. ZM-447439 targets Aurora kinases, whose inhibition disrupts the associated kinase-dependent pathways that could regulate MS4A4D activity. Lastly, Bortezomib, by inhibiting the proteasome, prevents the degradation of regulatory proteins, thereby leading to an indirect inhibition of MS4A4D by stabilizing proteins that maintain MS4A4D in an inactive state.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, inhibits MS4A4D by interfering with tyrosine kinase-dependent signaling pathways. MS4A4D function relies on phosphorylation events, and genistein's inhibition of these kinases leads to a decrease in MS4A4D activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2, a Src family kinase inhibitor, inhibits MS4A4D by preventing Src-related kinases from phosphorylating substrates, which is a step required for full activation of several proteins, including MS4A4D. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, inhibits MS4A4D by blocking the PI3K/Akt signaling pathway. Given that PI3K is upstream of many cellular functions, its inhibition can lead to decreased activation of proteins like MS4A4D that are regulated by this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, an inhibitor of MEK, inhibits MS4A4D by blocking the MAPK/ERK pathway, which can be involved in the regulation of MS4A4D activity, leading to its functional inhibition due to lack of necessary phosphorylation events. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, another MEK inhibitor, inhibits MS4A4D by blocking the same MAPK/ERK signaling pathway as PD98059, leading to a similar functional inhibition through prevention of phosphorylation processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, inhibits MS4A4D by blocking the p38 MAPK pathway. MS4A4D, being associated with signaling processes, is functionally inhibited when this kinase pathway is inactivated. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125, an inhibitor of JNK, inhibits MS4A4D by blocking the JNK signaling pathway, another pathway potentially involved in the regulation of MS4A4D, preventing its activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, like LY294002, is a PI3K inhibitor and inhibits MS4A4D by impairing the PI3K/Akt pathway, leading to a reduction in MS4A4D functional activity due to decreased phosphorylation and activation downstream of PI3K. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, inhibits MS4A4D by blocking the mTOR signaling pathway, which is crucial for many cellular processes. The inhibition of mTOR can lead to reduced activity of MS4A4D as it could be downstream of mTOR-regulated pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632, a ROCK inhibitor, inhibits MS4A4D by impeding the Rho/ROCK pathway. This signaling pathway is known to be involved in various cellular functions, and its inhibition can lead to decreased MS4A4D activity. | ||||||