MS4A4D Activators
MS4A4D Activators are a diverse group of chemical compounds that facilitate the functional enhancement of MS4A4D through distinct signaling pathways and mechanisms. Forskolin, by raising intracellular cAMP levels, indirectly augments MS4A4D activity through PKA activation, which in turn may phosphorylate proteins within the signaling pathways that MS4A4D is part of. Similarly, 8-Bromo-cAMP serves as a cAMP analog to activate PKA and potentially enhance MS4A4D's functional role. Sphingosine-1-phosphate, through its interaction with S1P receptors, initiates signaling cascades that could lead to the activation of pathways involving MS4A4D, while PMA activates PKC, further influencing the phosphorylation state and activity of proteins in MS4A4D-related pathways. Ionomycin and A23187 both act as calcium ionophores, increasing intracellular calciumlevels and activating calcium-dependent pathways that are likely to enhance MS4A4D activity. Additionally, Thapsigargin disrupts calcium homeostasis by inhibiting the SERCA pump, leading to calcium-mediated signaling events that may indirectly stimulate MS4A4D functional activity.
The modulation of kinase signaling also plays a crucial role in the indirect activation of MS4A4D. LY294002 and U0126, by inhibiting PI3K and MEK1/2 respectively, can shift cellular signaling dynamics to favor pathways in which MS4A4D is implicated, potentially enhancing its activity. SB203580 acts similarly by specifically inhibiting p38 MAPK, altering signaling networks to potentially benefit those involving MS4A4D. Genistein's role as a tyrosine kinase inhibitor reduces competition from other signaling routes, which may allow MS4A4D-associated pathways to become more active. Lastly, the role of NAD+ in modulating sirtuin activity offers a more indirect route to influence MS4A4D activity through redox reactions and deacetylation processes, further highlighting the complex interplay of signaling molecules in the regulation of MS4A4D. Collectively, these activators operate through a multifaceted network of cellular signals to enhance the functional activity of MS4A4D without directly affecting its expression levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
A potent activator of adenylyl cyclase, Forskolin increases intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate proteins and influence signaling pathways that MS4A4D is involved in, thereby potentially enhancing MS4A4D's functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
As a bioactive lipid, Sphingosine-1-phosphate (S1P) engages with S1P receptors, triggering intracellular signaling cascades that can lead to the activation of pathways MS4A4D participates in, thus enhancing MS4A4D's functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins that are part of the signaling networks involving MS4A4D, possibly enhancing MS4A4D's functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling pathways. This activation can indirectly enhance the activity of MS4A4D through calcium-mediated signaling events. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, LY294002 blocks the PI3K/Akt pathway, which could shift the balance of signaling towards pathways that MS4A4D is directly involved in, potentially enhancing MS4A4D activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, leading to the suppression of the MAPK/ERK pathway. This suppression can indirectly enhance MS4A4D activity by affecting signaling networks that MS4A4D is part of. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, which may indirectly enhance MS4A4D activity by altering signaling pathways that MS4A4D is associated with, due to the interplay of signaling cascades. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can enhance MS4A4D activity by reducing competitive signaling pathways, thus potentially allowing MS4A4D-related pathways to become more prominent. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ serves as a coenzyme in redox reactions and can influence sirtuin activity. By modulating sirtuin and other NAD+-dependent deacetylases, NAD+ can indirectly influence the signaling pathways that MS4A4D is involved in. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, leading to an increase in cytosolic calcium levels. This elevation in calcium can activate calcium-dependent signaling mechanisms that may enhance MS4A4D activity. | ||||||