Date published: 2026-4-1

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MRP-L53 Inhibitors

MRP-L53 protein, potentially altering its structural conformation and thereby obstructing its substrate binding or transport capacity. Others may integrate into the lipid milieu of the cell membrane, influencing the protein's localization or membrane dynamics, which are crucial for its function. Additionally, certain inhibitors could modulate the cellular energy states, since MRP transporters typically rely on ATP; thus, inhibitors targeting cellular ATP levels or obstructing ATP-binding sites on MRP-L53 could significantly reduce its transport efficiency. Furthermore, these compounds may also exert influence by engaging with cellular signaling pathways, thereby regulating the expression or turnover of MRP-L53, leading to changes in the protein's intracellular concentration. This indirect route of inhibition serves as a strategic point of intervention, which could result in the attenuation of the protein's functional expression within the cellular context. In their overall action, these inhibitors are characterized by diverse chemical structures, which underlie their varying affinities for the MRP-L53 protein and dictate their specific mode of interaction.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Calcium channel blocker that alters cell membrane potential and can indirectly affect the energy state of MRP transporters.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Immunosuppressant that can bind to multiple proteins and may alter MRP transporter function by changing membrane dynamics.

MK-571

115103-85-0sc-201340
sc-201340A
5 mg
25 mg
$109.00
$421.00
8
(2)

Leukotriene receptor antagonist known to inhibit MRP-related transporters by competitive inhibition at the substrate site.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$29.00
$38.00
18
(1)

Can affect membrane-associated proteins and potentially alter MRP transporter activity.

Probenecid

57-66-9sc-202773
sc-202773A
sc-202773B
sc-202773C
1 g
5 g
25 g
100 g
$28.00
$39.00
$100.00
$277.00
28
(2)

Inhibits organic anion transporters and may have an off-target effect on MRP-related transporters by competitive inhibition.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Flavonoid that has been shown to modulate various protein functions, possibly affecting MRP transporter activity through non-specific interactions.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Polyphenol with multiple cellular targets, which could alter the function of MRP transporters by modifying the lipid environment of the membrane.

Reserpine

50-55-5sc-203370
sc-203370A
1 g
5 g
$137.00
$414.00
1
(2)

Alkaloid that disrupts vesicular storage of monoamines and may indirectly affect MRP transporters by altering cellular homeostasis.

Tamoxifen

10540-29-1sc-208414
2.5 g
$272.00
18
(2)

Selective estrogen receptor modulator that can modulate cell signaling pathways and potentially impact MRP transporter activity.

(±)-Sulfinpyrazone

57-96-5sc-202822
sc-202822A
1 g
5 g
$42.00
$94.00
2
(1)

Uricosuric agent that may competitively inhibit MRP-related transporters through its action on renal organic anion transport.