MK-571 (CAS 115103-85-0)
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MK-571 has been reported to be a selective competitive inhibitor of [3H]leukrotriene D4 (LTD4) binding to CysLT1 receptors. LTD4 may act to induce contractions in guinea pig trachea and human lung membranes. This compound demonstrates inhibitory characteristics of Mdr-1 (multidrug resistance protein-1) mediated transport. Additionally, studies suggest that this agent can augment the effects of cytotoxic agents on cells in vitro. MK-571 is an inhibitor of MRP1 and CysLT1 Receptor. The extensive utilization of MK-571 in scientific research studies can be attributed to its remarkable ability to hinder the activity of leukotriene D4. MK-571 is primarily explored in research focused on its function as a leukotriene receptor antagonist. It facilitates the study of leukotriene pathways, which are for understanding inflammatory processes.
MK-571 (CAS 115103-85-0) References
- Characterization of the human cysteinyl leukotriene CysLT1 receptor. | Lynch, KR., et al. 1999. Nature. 399: 789-93. PMID: 10391245
- Characterization of the human cysteinyl leukotriene 2 receptor. | Heise, CE., et al. 2000. J Biol Chem. 275: 30531-6. PMID: 10851239
- Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. | Blain, JF. and Sirois, P. 2000. Prostaglandins Leukot Essent Fatty Acids. 62: 361-8. PMID: 10913229
- Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. | Ogasawara, H., et al. 2002. J Biol Chem. 277: 18763-8. PMID: 11854273
- Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model. | Wong, WS., et al. 2007. Eur J Pharmacol. 575: 134-41. PMID: 17689528
- The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta. | Rahi, MM., et al. 2009. Eur J Pharm Sci. 37: 588-92. PMID: 19454316
- MK-571 attenuates kidney ischemia and reperfusion-induced airway hypersensitivity in rats. | Wu, NC., et al. 2014. Transplant Proc. 46: 1127-30. PMID: 24815144
- Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. | Jones, TR., et al. 1989. Can J Physiol Pharmacol. 67: 17-28. PMID: 2540892
- Hepatic Warm Ischemia-Reperfusion-Induced Increase in Pulmonary Capillary Filtration Is Ameliorated by Administration of a Multidrug Resistance-Associated Protein 1 Inhibitor and Leukotriene D4 Antagonist (MK-571) Through Reducing Neutrophil Infiltration and Pulmonary Inflammation and Oxidative Stress in Rats. | Yeh, DY., et al. 2015. Transplant Proc. 47: 1087-91. PMID: 26036526
- Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2',7'-Dichloroflourescein Disposition in Caco-2 Cells. | Drennen, C., et al. 2018. J Pharm Sci. 107: 1194-1203. PMID: 29247742
- Inhibition of Multidrug Resistance Proteins by MK 571 Enhances Bladder, Prostate, and Urethra Relaxation through cAMP or cGMP Accumulation. | Bertollotto, GM., et al. 2018. J Pharmacol Exp Ther. 367: 138-146. PMID: 30108158
- MK-571, a Cysteinyl Leukotriene Receptor 1 Antagonist, Inhibits Hepatitis C Virus Replication. | Ruiz, I., et al. 2020. Antimicrob Agents Chemother. 64: PMID: 32179525
- Transplacental transfer of acetaminophen in pregnant rats. | Chen, JH., et al. 2022. Biomed Pharmacother. 154: 113613. PMID: 36058146
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MK-571, 5 mg | sc-201340 | 5 mg | $107.00 | |||
MK-571, 25 mg | sc-201340A | 25 mg | $413.00 |