MPP10 Inhibitors

The class of MPP10 Inhibitors refers to a diverse group of chemical compounds that indirectly affect the function of MPP10 by disrupting the cellular processes necessary for the proper biogenesis and function of ribosomes. MPP10 plays a role in the early steps of pre-rRNA processing, and its activity is tightly connected to the synthesis and maturation of ribosomal RNA. Compounds like Actinomycin D, CX-5461, and BMH-21 impair RNA polymerase I activity, which is essential for the transcription of rRNA, thus indirectly affecting MPP10's function. Mycophenolic acid and Ribavirin reduce the availability of precursors necessary for rRNA synthesis, which would consequently influence MPP10's role in ribosome assembly.

5-Fluorouracil, Triptolide, Homoharringtonine, and similar compounds target various stages of RNA processing or protein synthesis. For instance, 5-Fluorouracil is incorporated into RNA, disrupting its processing and maturation, which can impair the function of proteins involved in rRNA maturation, including MPP10. Homoharringtonine inhibits the elongation step of protein synthesis, which can lead to ribosomal stress and possibly feedback inhibition on rRNA synthesis and processing. Leptomycin B, by blocking nuclear export, indirectly affects the availability of mature ribosomal subunits in the cytoplasm, which is a process MPP10 is indirectly associated with. Rocaglamide and Silvestrol, as inhibitors of translation initiation, can also induce a stress response that impacts rRNA synthesis and processing. Pladienolide B, by affecting splicing factors, can influence the maturation of ribosomal subunits, which would, in turn, affect MPP10's function.