MPDZ Inhibitors
MPDZ inhibitors are chemical compounds designed to specifically target and inhibit the activity of the multi-PDZ domain protein (MPDZ), a scaffolding protein that contains multiple PDZ (PSD-95/Dlg/ZO-1) domains. MPDZ plays a critical role in organizing protein-protein interactions at cellular junctions, particularly in tight junctions and synaptic sites. This protein is essential for maintaining cellular polarity and proper communication between cells, especially in tissues where barrier function and selective permeability are crucial, such as epithelial and endothelial tissues. MPDZ interacts with a variety of membrane-associated proteins, helping to coordinate the assembly and localization of proteins involved in signaling pathways, cell adhesion, and maintaining the structural integrity of junctional complexes.
Inhibitors of MPDZ work by binding to one or more of its PDZ domains, disrupting its ability to interact with target proteins. This inhibition interferes with the scaffolding function of MPDZ, potentially leading to destabilization of protein complexes at cell junctions and impairing their regulatory roles in cell adhesion and signaling. The inhibition of MPDZ provides researchers with valuable tools for studying the structural and functional roles of scaffolding proteins in maintaining cellular architecture and communication. By blocking MPDZ activity, scientists can explore the consequences of disrupted protein-protein interactions in various contexts, such as changes in barrier function, cellular polarity, and the organization of synaptic or junctional components. MPDZ inhibitors help unravel the complex interactions at play in maintaining the integrity of tight junctions and other cellular contact points, providing insights into the regulation of these essential cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate MPDZ expression by inhibiting histone deacetylase (HDAC) activity, leading to hyperacetylation of histones and altering transcription of the MPDZ gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could reduce MPDZ expression by incorporating into DNA and RNA, thereby inhibiting DNA methyltransferase, which can lead to hypomethylation of the MPDZ gene promoter. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid (Vorinostat) may lead to decreased expression of MPDZ by inhibiting HDACs, resulting in an open chromatin state at the MPDZ locus that is less conducive to transcription. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 could decrease MPDZ gene expression by directly inhibiting DNA methyltransferases, leading to persistent hypomethylation of the MPDZ gene promoter and reduced transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine (Decitabine) has the potential to decrease MPDZ expression by inhibiting DNA methyltransferase, which may result in a hypomethylated state of the MPDZ promoter, thereby reducing transcription efficiency. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A could inhibit transcription of the MPDZ gene by binding DNA in the gene′s promoter region, blocking the binding of transcription factors required for MPDZ gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine could reduce MPDZ gene expression indirectly by disrupting endolysosomal trafficking, which may lead to alterations in cellular signaling pathways that govern the transcription of the MPDZ gene. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 may downregulate MPDZ by inhibiting the activity of BET bromodomain proteins, which play a role in the regulation of gene expression, including the expression of MPDZ. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may decrease MPDZ gene expression by chelating metal ions that are cofactors for transcription factors or enzymes involved in the transcription of the MPDZ gene. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may inhibit the transcription of the MPDZ gene by interfering with the activity of transcription factors or transcriptional coactivators necessary for the initiation and elongation phases of MPDZ gene transcription. | ||||||