MEF-2A Activators
The chemical class MEF-2A Activators is comprised of a diverse array of compounds that can enhance the activity of MEF-2A by modulating signaling pathways and cellular processes. These compounds utilize different mechanisms to affect the activity of MEF-2A either through direct phosphorylation events, as seen with agents like Forskolin and Isoproterenol, which increase cAMP levels and subsequently activate PKA, or through altering intracellular calcium levels with agents like A23187, thereby impacting CaMK activity. PKA and CaMK are well-documented kinases that can phosphorylate and activate MEF-2A, increasing its transcriptional activity.
Other compounds within this class, such as PMA and EGCG, activate PKC or modulate various signaling pathways, respectively, also leading to the activation of MEF-2A. Retinoic acid and Valsartan work through gene expression modulation, while lithium chloride exerts its effects by inhibiting GSK-3β, thus preventing the inhibitory phosphorylation of MEF-2A. Compounds like 5-Azacytidine affect the epigenetic landscape, potentially enhancing the expression of proteins that activate MEF-2A. Finally, Sildenafil and HDAC inhibitors like Trichostatin A indirectly influence MEF-2A activity by modulating the NO pathway and chromatin structure, respectively.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn can activate PKA. Activated PKA can phosphorylate and thereby activate MEF-2A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and regulate MEF-2A, leading to its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which can activate calmodulin-dependent kinase (CaMK). CaMK can phosphorylate MEF-2A, enhancing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that can increase cAMP levels, thereby potentially activating PKA and influencing MEF-2A activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cAMP analog that activates PKA. PKA can phosphorylate MEF-2A, which can increase MEF-2A's transcriptional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can modulate various signaling pathways, including those affecting CaMK, which in turn can activate MEF-2A. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression and differentiation pathways, which can include the activation of signaling cascades that phosphorylate and activate MEF-2A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3β, a kinase that can phosphorylate MEF-2A, leading to its activation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can cause DNA demethylation, potentially affecting the expression of genes that encode proteins involved in MEF-2A activation pathways. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $40.00 $92.00 $122.00 | 4 | |
Valsartan activates PPAR-γ, which can lead to the upregulation of MEF-2A activity through cross-talk between PPAR-γ and MEF-2A signaling pathways. | ||||||