MBD3L5 Inhibitors
The chemical class of MBD3L5 inhibitors encompasses compounds that impede the functional activity of the MBD3L5 protein. MBD3L5's role involves binding to methylated DNA; therefore, agents that alter DNA methylation patterns can modulate the protein's activity. For example, 5-Azacytidine, a nucleoside analog of cytidine, can be incorporated into DNA during replication and RNA during transcription, which leads to the inhibition of DNA methyltransferases and subsequent DNA demethylation. This reduction in DNA methylation levels can result in decreased binding of MBD3L5 to DNA, thereby inhibiting its activity. Similarly, RG108, a non-nucleoside inhibitor, directly targets DNA methyltransferases, preventing the methylation of cytosines within the DNA molecule. This inhibition of DNA methylation diminishes the methylated DNA substrate available for MBD3L5, leading to a functional decrease in the protein's activity.
Other compounds, such as procaine and hydralazine, although not initially developed as DNA methylation modifiers, have been observed to possess DNA demethylating activities. Procaine, by interfering with DNA methylation, can affect the epigenetic regulation of gene expression, which includes reducing the binding affinity of MBD3L5 to methylated DNA.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into DNA and RNA, which can lead to the demethylation of DNA. MBD3L5 binds to methylated DNA, so demethylation can reduce the binding of MBD3L5 to DNA, thereby inhibiting its function. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, which prevents the methylation of DNA. It would decrease the availability of methylated DNA substrates for MBD3L5, thus inhibiting its activity. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
A DNA-demethylating agent that by altering DNA methylation status can affect the binding of proteins like MBD3L5 to methylated DNA, leading to a functional decrease in MBD3L5 activity. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
An antihypertensive agent also known to demethylate DNA and may thus disrupt the interaction between MBD3L5 and its methylated DNA targets. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine analog that traps DNA methyltransferases, leading to passive demethylation of DNA. Reduced methylation can inhibit MBD3L5 binding to DNA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A hypomethylating agent that can inhibit DNA methyltransferases, leading to a decrease in DNA methylation and consequently reducing MBD3L5's ability to bind its target DNA sequences. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A natural compound found in green tea that has been shown to demethylate DNA. This would decrease the methylated DNA binding sites for MBD3L5, inhibiting its function. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An inhibitor of DNA methyltransferase, which can indirectly lead to hypomethylation of DNA and potentially reduce MBD3L5's DNA binding activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that has been reported to have DNA demethylating activity, which could limit MBD3L5's interaction with methylated DNA. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that acts as a DNA methyltransferase inhibitor, potentially reducing DNA methylation and the subsequent binding of MBD3L5 to DNA. | ||||||