Date published: 2026-2-14

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MBD3L5 Inhibitors

The chemical class of MBD3L5 inhibitors encompasses compounds that impede the functional activity of the MBD3L5 protein. MBD3L5's role involves binding to methylated DNA; therefore, agents that alter DNA methylation patterns can modulate the protein's activity. For example, 5-Azacytidine, a nucleoside analog of cytidine, can be incorporated into DNA during replication and RNA during transcription, which leads to the inhibition of DNA methyltransferases and subsequent DNA demethylation. This reduction in DNA methylation levels can result in decreased binding of MBD3L5 to DNA, thereby inhibiting its activity. Similarly, RG108, a non-nucleoside inhibitor, directly targets DNA methyltransferases, preventing the methylation of cytosines within the DNA molecule. This inhibition of DNA methylation diminishes the methylated DNA substrate available for MBD3L5, leading to a functional decrease in the protein's activity.

Other compounds, such as procaine and hydralazine, although not initially developed as DNA methylation modifiers, have been observed to possess DNA demethylating activities. Procaine, by interfering with DNA methylation, can affect the epigenetic regulation of gene expression, which includes reducing the binding affinity of MBD3L5 to methylated DNA.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

A cytidine analog that incorporates into DNA and RNA, which can lead to the demethylation of DNA. MBD3L5 binds to methylated DNA, so demethylation can reduce the binding of MBD3L5 to DNA, thereby inhibiting its function.

RG 108

48208-26-0sc-204235
sc-204235A
10 mg
50 mg
$131.00
$515.00
2
(1)

A non-nucleoside DNA methyltransferase inhibitor, which prevents the methylation of DNA. It would decrease the availability of methylated DNA substrates for MBD3L5, thus inhibiting its activity.

Procaine

59-46-1sc-296134
sc-296134A
sc-296134B
sc-296134C
25 g
50 g
500 g
1 kg
$110.00
$193.00
$407.00
$628.00
1
(0)

A DNA-demethylating agent that by altering DNA methylation status can affect the binding of proteins like MBD3L5 to methylated DNA, leading to a functional decrease in MBD3L5 activity.

Hydralazine-15N4 Hydrochloride

304-20-1 (unlabeled)sc-490605
1 mg
$480.00
(0)

An antihypertensive agent also known to demethylate DNA and may thus disrupt the interaction between MBD3L5 and its methylated DNA targets.

Zebularine

3690-10-6sc-203315
sc-203315A
sc-203315B
10 mg
25 mg
100 mg
$129.00
$284.00
$1004.00
3
(1)

A cytidine analog that traps DNA methyltransferases, leading to passive demethylation of DNA. Reduced methylation can inhibit MBD3L5 binding to DNA.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

A hypomethylating agent that can inhibit DNA methyltransferases, leading to a decrease in DNA methylation and consequently reducing MBD3L5's ability to bind its target DNA sequences.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

A natural compound found in green tea that has been shown to demethylate DNA. This would decrease the methylated DNA binding sites for MBD3L5, inhibiting its function.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

An inhibitor of DNA methyltransferase, which can indirectly lead to hypomethylation of DNA and potentially reduce MBD3L5's DNA binding activity.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

A flavonoid that has been reported to have DNA demethylating activity, which could limit MBD3L5's interaction with methylated DNA.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

An isoflavone that acts as a DNA methyltransferase inhibitor, potentially reducing DNA methylation and the subsequent binding of MBD3L5 to DNA.