MBD3L5 Activators
MBD3L5 function through various pathways to enhance its phosphorylation and subsequent activation. Forskolin is a direct stimulant of adenylyl cyclase, leading to elevated cyclic AMP (cAMP) levels within the cell. This increase in cAMP results in the activation of protein kinase A (PKA), which then phosphorylates MBD3L5, leading to its activation. IBMX operates by inhibiting phosphodiesterases, enzymes responsible for cAMP breakdown, thus maintaining high intracellular levels of cAMP and indirectly sustaining PKA activity. Similarly, Epinephrine interacts with adrenergic receptors, which also triggers adenylyl cyclase activity, thereby raising cAMP levels and activating PKA, which in turn may phosphorylate MBD3L5. Isoproterenol, a synthetic catecholamine, and Terbutaline, a beta2-adrenergic agonist, both activate their respective receptors, resulting in increased cAMP production and PKA activation, leading to the phosphorylation of MBD3L5.
PGE1 binds to its specific receptors to activate adenylyl cyclase, which boosts cAMP and activates PKA, which can then target MBD3L5. Rolipram, as a selective inhibitor of phosphodiesterase 4 (PDE4), and Anagrelide, which inhibits phosphodiesterase III, both work to increase cAMP levels, thereby enhancing PKA activity that may phosphorylate MBD3L5. Cilostazol also inhibits phosphodiesterase III, leading to a similar cascade of intracellular events culminating in the phosphorylation of MBD3L5. Furthermore, Dobutamine's action on beta1-adrenergic receptors similarly leads to PKA-mediated phosphorylation of MBD3L5. Lastly, Salbutamol and Albuterol, both beta2-adrenergic agonists, act through the cAMP-PKA pathway, whereby PKA phosphorylates and activates MBD3L5, illustrating a common mechanism by which these chemical activators regulate MBD3L5 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, which increases cyclic AMP (cAMP) levels in cells. Elevated cAMP levels can lead to the activation of protein kinase A (PKA), which may phosphorylate MBD3L5, leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP. By maintaining high levels of cAMP, IBMX indirectly sustains PKA activity which may lead to the phosphorylation and activation of MBD3L5. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine interacts with adrenergic receptors, which can lead to the activation of adenylyl cyclase and an increase in cAMP levels. This cascade can result in the activation of PKA, potentially leading to the phosphorylation and activation of MBD3L5. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, resulting in increased cAMP production and PKA activation. PKA may then phosphorylate and activate MBD3L5. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Prostaglandin E1 (PGE1) binds to its receptors, leading to adenylyl cyclase activation and a rise in intracellular cAMP levels. The subsequent activation of PKA may then phosphorylate and activate MBD3L5. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels in the cell. This upregulation of cAMP can enhance PKA activity, which could phosphorylate and activate MBD3L5. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist which leads to the activation of adenylyl cyclase and an increase in cAMP. Elevated cAMP levels activate PKA, which can then phosphorylate and activate MBD3L5. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol activates beta2-adrenergic receptors, increasing cAMP production and activating PKA. PKA can phosphorylate substrates including MBD3L5, leading to its activation. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol inhibits phosphodiesterase III which leads to an increase in cAMP levels and PKA activation. PKA then can phosphorylate and activate MBD3L5. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine acts on beta1-adrenergic receptors, causing an increase in cAMP levels and activating PKA. Activated PKA may be capable of phosphorylating and activating MBD3L5. | ||||||