Molecular structure of Procaine, CAS Number: 59-46-1
Procaine (CAS 59-46-1)
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Alternate Names:
2-(Diethylamino)ethyl-4-aminobenzoate; 4-Aminobenzoic acid 2-(diethylamino) ethyl ester;Novocaine; Vitamin H3
Application:
Procaine is a sodium channel blocker and inhibitor of a variety of processes
CAS Number:
59-46-1
Purity:
≥98%
Molecular Weight:
236.31
Molecular Formula:
C13H20N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demetylation and reactivation of methylation-silenced genes such as RARbeta and GSTP1. In studies utilizing a neuroblastoma cell line (SHEP), procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line HEK293 (WCL: sc-45136), the presence of procaine is reported to potently inhibit AChR (nicotinic acetylcholine receptors).
Procaine (CAS 59-46-1) References
- Apoptosis induction by different local anaesthetics in a neuroblastoma cell line. | Werdehausen, R., et al. 2009. Br J Anaesth. 103: 711-8. PMID: 19700777
- Calcium-induced calcium release in skeletal muscle. | Endo, M. 2009. Physiol Rev. 89: 1153-76. PMID: 19789379
- Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells. | Gao, Z., et al. 2009. Oncol Rep. 22: 1479-84. PMID: 19885602
- The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants. | Wang, H., et al. 2010. Eur J Pharmacol. 630: 29-33. PMID: 20045405
- A wasp manipulates neuronal activity in the sub-esophageal ganglion to decrease the drive for walking in its cockroach prey. | Gal, R. and Libersat, F. 2010. PLoS One. 5: e10019. PMID: 20383324
- Piglets' acute responses to local anesthetic injection and surgical castration: Effects of the injection method and interval between injection and castration. | Coutant, M., et al. 2022. Front Vet Sci. 9: 1009858. PMID: 36246321
- One-Step Preparation of Carboxymethyl Cellulose-Phytic Acid Hydrogels with Potential for Biomedical Applications. | Ghilan, A., et al. 2022. Gels. 8: PMID: 36286150
- Comparative Study of Pain-Related Responses of Male Piglets up to Seven Days of Age to the Application of Different Local Anaesthetics and Subsequent Castration. | Söbbeler, FJ., et al. 2022. Animals (Basel). 12: PMID: 36290223
- Procaine Abrogates the Epithelial-Mesenchymal Transition Process through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma. | Yang, MH., et al. 2022. Cancers (Basel). 14: PMID: 36291760
- Compensability of an enhanced incidence of spermatozoa with cytoplasmic droplets in boar semen for use in artificial insemination: a single cell approach. | Henning, H., et al. 2022. Sci Rep. 12: 21833. PMID: 36528611
- Thermodynamic Correlation between Liquid-Liquid Phase Separation and Crystalline Solubility of Drug-Like Molecules. | Uekusa, T., et al. 2022. Pharmaceutics. 14: PMID: 36559054
- Parasitoid wasp venom re-programs host behavior through downmodulation of brain central complex activity and motor output. | Rana, A., et al. 2023. J Exp Biol. 226: PMID: 36700409
- Crystallization of short-acting and intermediate-acting local anesthetics when mixed with adjuvants: a semiquantitative light microscopy analysis. | Hoerner, E., et al. 2023. Reg Anesth Pain Med.. PMID: 36928300
- Expanding the Monolayer Scope for Nucleic Acid-Based Electrochemical Sensors Beyond Thiols on Gold: Alkylphosphonic Acids on ITO. | Shaver, A. and Arroyo-Currás, N. 2023. ECS Sens Plus. 2: 010601. PMID: 37006966
- A case of severe trigeminal neuralgia: recovery by means of stellate ganglion block with procaine. Discussion of possible mechanisms of action. | Lopes, CA. and Fischer, L. 2023. J Int Med Res. 51: 3000605231164479. PMID: 37086065
Inhibitor of:
2310079F23Rik, 7530422B04Rik, AChR, CNG-4, CNGA2, GATC, HEN1, Junctophilin-2, MBD3L2, MBD3L2-5, MBD3L5, MeCP2, MILI, NIT2, ODF3B, Olfr853, Olfr854, Olfr859, PCMT1, QRICH2, RASSF1A, RyR-3, Sperm-associated antigen (SPAG), Triadin, Troponin T-FS, and TSPY8.Activator of:
1700019N19Rik, 2310038E17Rik, 5-Methylcytidine, 7530422B04Rik, Dnmt3b, Histone cluster 1 H3H, HMG-1L, IP3R-III, MBD2, MBD3L4, N6AMT2, PRAMEF17, RyR-1, SAP 130, TCP-11, and ZNF382.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Procaine, 25 g | sc-296134 | 25 g | $108.00 | |||
Procaine, 50 g | sc-296134A | 50 g | $189.00 | |||
Procaine, 500 g | sc-296134B | 500 g | $399.00 | |||
Procaine, 1 kg | sc-296134C | 1 kg | $616.00 |