Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demetylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line HEK293 (WCL: sc-45136), the presence of procaine is reported to potently inhibit AChR (nicotinic acetylcholine receptors).
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Soluble in water (1 g/200ml), ether, benzene, chloroform, ethanol, ethyl ether, alcohol, and water (9.45X10+3 mg/l) at 30° C.
Desiccate at room temperature
373.6° C at 760 mmHg
Sodium channel protein type III alpha subunit: IC50 = 110 µM (human); Sodium channel protein type VIII alpha subunit: IC50 = 110 µM (human); Sodium channel protein type II alpha subunit: IC50 = 110 µM (human); Sodium channel protein type I alpha subunit: IC50 = 110 µM (human)
pKa= 8.05 @ 15 deg C pKb= 9.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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What is the appearance of the compound?
Asked by: two2igm05
Thank you for you question.
Procaine, sc-296134, is an off-white crystalline powder.
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