Procaine CAS: 59-46-1
MF: C13H20N2O2
MW: 236.31
A sodium channel blocker and inhibitor of a variety of processes.

Procaine (CAS 59-46-1)

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Alternate Names: 2-(Diethylamino)ethyl-4-aminobenzoate; 4-Aminobenzoic acid 2-(diethylamino) ethyl ester;Novocaine; Vitamin H3
Application: Procaine is a sodium channel blocker and inhibitor of a variety of processes
CAS Number: 59-46-1
Purity: ≥98%
Molecular Weight: 236.31
Molecular Formula: C13H20N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demetylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line HEK293 (WCL: sc-45136), the presence of procaine is reported to potently inhibit AChR (nicotinic acetylcholine receptors).


References

1. Werdehausen, R., et al. 2009. Br J Anaesth. 103: 711-718. PMID: 19700777
2. Gao, Z., et al. 2009. Oncol. Rep. 22: 1479-1484. PMID: 19885602
3. Endo, M. 2009. Physiol. Rev. 89: 1153-1176. PMID: 19789379
4. Wang, H., et al. 2010. Eur. J. Pharmacol. 630: 29-33. PMID: 20045405
5. Gal, R. and Libersat, F. 2010. PLoS ONE. 5: e10019. PMID: 20383324

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (1 g/200ml), ether, benzene, chloroform, ethanol, ethyl ether, alcohol, and water (9.45X10+3 mg/l) at 30° C.
Storage :
Desiccate at room temperature
Melting Point :
61° C
Boiling Point :
373.6° C at 760 mmHg
Density :
1.08 g/cm3
Refractive Index :
n20D 1.54
IC50 :
Sodium channel protein type III alpha subunit: IC50 = 110 µM (human); Sodium channel protein type VIII alpha subunit: IC50 = 110 µM (human); Sodium channel protein type II alpha subunit: IC50 = 110 µM (human); Sodium channel protein type I alpha subunit: IC50 = 110 µM (human)
pK Values :
pKa= 8.05 @ 15 deg C pKb= 9.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DG2100000
PubChem CID :
4914
Merck Index :
14: 7757
MDL Number :
MFCD00007893
EC Number :
200-426-9
Beilstein Registry :
0913480
SMILES :
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for you question. Procaine, sc-296134, is an off-white crystalline powder.
Answered by: TechService7
Date published: 2017-02-06
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