MAPBPIP Activators
MAPBPIP activators are a class of compounds that enhance the functional activity of MAPBPIP, a protein implicated in lysosome biogenesis and endosome-lysosome trafficking. These activators exert their effects by modulating distinct biochemical pathways that regulate the function of MAPBPIP. They include compounds such as Rapamycin and Curcumin, which influence the mTOR and NRF2 pathways respectively, leading to enhanced MAPBPIP functional activity. Other compounds such as Forskolin and Resveratrol modulate the AC and PI3K/AKT pathways respectively, leading to increased MAPBPIP activity.
Capsaicin and Genistein, for example, work through the TRPV1 and PI3K/AKT pathways respectively, promoting MAPBPIP function. Berberine and Salicylic Acid are also part of this class, impacting AMPK pathway to upregulate MAPBPIP. Another compound, Caffeine, influences the PDE pathway, leading to enhanced MAPBPIP functionality. Quercetin and Berberine affect the PI3K/AKT and AMPK pathways respectively, leading to enhanced MAPBPIP activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway. Inhibition of this pathway releases MAPBPIP from mTORC1, enhancing its functional activity in lysosome biogenesis and endosome-lysosome trafficking. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates the NRF2 pathway. Activation of NRF2 can stimulate MAPBPIP activity, which is essential for maintaining lysosomal function and autophagy. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates the Adenylyl cyclase (AC) pathway, which in turn increases the intracellular level of cAMP. Increased cAMP can enhance MAPBPIP activity in lysosome biogenesis and endosome-lysosome trafficking. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol inhibits the PI3K/AKT pathway. Inhibition of this pathway can lead to the enhancement of MAPBPIP activity, as the PI3K/AKT pathway negatively regulates MAPBPIP. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates the AMPK pathway. By activating AMPK, metformin indirectly enhances the function of MAPBPIP, which is crucial for lysosome biogenesis and autophagy. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the NRF2 pathway. Activation of this pathway can stimulate MAPBPIP activity, which plays a pivotal role in maintaining lysosomal function and autophagy. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits the phosphodiesterase (PDE) pathway, leading to increased cAMP levels. Increased cAMP can enhance MAPBPIP activity in lysosome biogenesis and endosome-lysosome trafficking. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates the TRPV1 pathway, which can increase intracellular calcium levels. Increased calcium can enhance MAPBPIP activity, which is essential for lysosome biogenesis and endosome-lysosome trafficking. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates the AMPK pathway. Activation of AMPK indirectly enhances the function of MAPBPIP, which is crucial for lysosome biogenesis and autophagy. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits the PI3K/AKT pathway. Inhibition of this pathway enhances MAPBPIP activity, as the PI3K/AKT pathway negatively regulates MAPBPIP. | ||||||