Molecular structure of Metformin-d6, Hydrochloride, CAS Number: 1185166-01-1
Metformin-d6, Hydrochloride (CAS 1185166-01-1)
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Alternate Names:
N,N-Dimethylimidodicarbonimidic Diamide-d6, Hydrochloride; Metformin-(dimethyl-d6) hydrochloride
Application:
Metformin-d6, Hydrochloride is a deuterium labeled oral hypoglycemic agent
CAS Number:
1185166-01-1
Molecular Weight:
171.66
Molecular Formula:
C4H6D6ClN5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Metformin-d6, Hydrochloride is employed in bioanalytical studies as an internal standard for the quantification of metformin using mass spectrometry techniques. This deuterated compound is particularly valuable in kinetic studies to understand how metformin is absorbed and distributed in biological systems. Researchers use Metformin-d6, Hydrochloride to ensure precise and accurate measurement of metformin in biological samples, due to its structural similarity and increased stability which provides a consistent reference point. It′s also used in the calibration of analytical instruments, aiding in the validation of analytical methods aimed at detecting and quantifying small molecules in complex matrices. In environmental science, Metformin-d6, Hydrochloride helps in tracing the environmental pathways and degradation of metformin, contributing to the study of pharmaceuticals as environmental contaminants.
Metformin-d6, Hydrochloride (CAS 1185166-01-1) References
- Optimization of a Modified QuEChERS Method for Multiresidue Analysis of Pharmaceuticals and Personal Care Products in Sewage and Surface Water by LC-MS/MS. | Kachhawaha, AS., et al. 2017. J AOAC Int. 100: 592-597. PMID: 28300022
- The Liver Circadian Clock Modulates Biochemical and Physiological Responses to Metformin. | Henriksson, E., et al. 2017. J Biol Rhythms. 32: 345-358. PMID: 28816632
- Pharmacokinetics and oral bioavailability of metformin hydrochloride in healthy mixed-breed dogs. | Johnston, CA., et al. 2017. Am J Vet Res. 78: 1193-1199. PMID: 28945132
- Study on Drug-Drug Interactions Between Chiglitazar, a Novel PPAR Pan-Agonist, and Metformin Hydrochloride in Healthy Subjects. | Yi, L., et al. 2019. Clin Pharmacol Drug Dev. 8: 934-941. PMID: 30809967
- Development of a new GC-MS/MS method for the determination of metformin in human hair. | Arbouche, N., et al. 2020. Drug Test Anal. 12: 1380-1386. PMID: 32472626
- Specific interpretation of hair concentrations in 2 fatal metformin intoxication cases. | Arbouche, N., et al. 2021. Leg Med (Tokyo). 48: 101803. PMID: 33109450
- Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. | Le Couteur, DG., et al. 2021. Cell Metab. 33: 2367-2379.e4. PMID: 34767745
- Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease. | Kazkayasi, I., et al. 2022. Life Sci. 299: 120538. PMID: 35395244
Inhibitor of:
ACAD-9, ACOT12, Angptl5, apoA-IV, BBS4, BCKDE1A, BCKDK, Calgranulin C, CARKL, CROT, DECR1, FGGY, GABP-β1, GPD1, GPT2, HM74B, IDH3B, Laforin, Lipocalin-13, liver FBPase, Metallothionein 3, NDUFA4L2, PHD, PHKB, PTRH2, Rag C, SEMA6C, SerpinA3k, SLC25A29, SPATA18, T-FABP, TMEM18, and TMEM43.Activator of:
β-Dystrobrevin, 2400001E08Rik, AATC, ABHD4, ACAA2, ACAD-11, ACBD7, ACMSD, ACOT2, ACSVL1, AFG3L2, AKAP 8L, Alpha 4, AMPD2, AMPKγ3, ANT1, APBB1IP, APC1, APC8, APIP, apoOL, AQP7, ARFGAP1/3, ARMER, ATAD3A, ATAD3B, Ataxin-7, Atg13, Atg9a, Atg9b, ATP5G3, BBS1, BBS3, BDP1, BLOS2, BRP44L, BTG4, BXDC2, C22orf42, C4BPαZ, CA XIII, CCDC25, CCDC8, CDS2, Centaurin γ3, CHCHD3, CHCHD4, CHES1, CIDE-B, CLN6, CLS1, collectrin, COX15, COX4I2, COX7a1, CPPED1, CPS2, CRBN, CRIP2, CTAGE2, CTMP, CTP Synthase 2, CTRP3, Cvt19, cystatin F, DAGLβ, DAK, DGUOK, DHTKD1, DNA pol γ2, DP-3, Dpb11, DPPX, eIF2Bε, eIF3α, eIF3ζ, eIF6, ExoC3L2, FAM110C, FASTKD3, FNDC3A, FOXJ2, FOXK2, FOXO6, FUNDC1, GABARAPL1, GCAT, GCDH, GDF-9, Gemin4, Gemin8, Genethonin-1, GLIS2, Glut10, Glut11, Glut12, GPR116, GPR43, Grim19, HAL, HEI10, HSPBAP1, ICF45, ICT1, IGFBP4, IMMP2L, IMPACT, Integrin α4, IP6K1, IRG1, JTV1, KIAA1432, lacritin, LANCL2, LAT2, LETM1, LIX1L, LONP1, LPAAT-δ, LZTR1, Maltase-glucoamylase, Mammaglobin A, MAP LC3γ, MAPBPIP, MATE2, MCT12, Med4, Meis3, MLL5, MPV17, MRP-L17, MRP-L18, MTRF1, MtRPOL, MULK, NAGS, NAPRT, ND5, NDC1, NDUFA10, NDUFA2, NDUFA6, NDUFAF1, NDUFAF6, NDUFB11, NEPH3, NHEDC2, nm23-H4, NOL10, NPAT, NPT2b, NRBF2, NRK1, NYGGF4, OFD1, OXA1L, p70 S6 kinase β, PAT4, Perp, PET100, PGAM4, Podocan, PPAN, PRCC, PRPS3, Psf3, PTCD1, PTER, PTP IA-2, Rab 7L1, Raly, RASL11B, rBAT, RBFA, Reg I, RGSL1, Ribosomal Protein L26, ROGDI, Rtl1, SAPS1, Seh1, SEMA4C, SETD2, SFXN5, Sialyltransferase 7A, SKIV2L2, SLC25A20, SLC25A23, SLC2A13, SLC35D1, SLC38A10, Slfn3, SLN, SMCR7, SMCR7L, SMCR8, Snf1, SRMS, SSSCA1, Stabilin-1, STK33, STK40, SUCLA2, Synaptotagmin XIV, TARSL2, TBC1D1, TBC1D15, TBCK, TDE1, TFB1M, TFB2M, TIG2, TMEM18, TMEM55B, TMEM71, TMEM86A, Trehalase, TRIM16, TRIM3, TRIM31, TRIM62, Tub, UBX, UCK2, UFSP2, ULK2, USP28, UVRAG, WIPI-1, WIPI-3, WIPI-4, WNK2, and YME1L1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metformin-d6, Hydrochloride, 1 mg | sc-218701 | 1 mg | $286.00 | |||
Metformin-d6, Hydrochloride, 5 mg | sc-218701A | 5 mg | $806.00 | |||
Metformin-d6, Hydrochloride, 10 mg | sc-218701B | 10 mg | $1510.00 |