MAGE-A9 Activators
MAGE-A9 activators represent a unique class of compounds that can enhance the functional activity of MAGE-A9 through various biochemical and cellular pathways. For instance, MG132 can increase the functional activity of MAGE-A9 by inhibiting the ubiquitin-proteasome pathway, thereby preventing the degradation of MAGE-A9. Similarly, Trichostatin A can enhance the functional activity of MAGE-A9 by inhibiting histone deacetylase, increasing the acetylation of histones associated with the MAGE-A9 gene. Inhibition of enzymes such as calpain by Calpeptin can also prevent the degradation of MAGE-A9 and thereby increase its functional activity.
Some of these compounds work by inhibiting key cellular processes that might negatively influence MAGE-A9's activity. For instance, Staurosporine is a potent inhibitor of protein kinases, which may phosphorylate and inactivate MAGE-A9, enhancing its functional activity. Similarly, LY294002, an inhibitor of PI3K, can negate the influence of PI3K-mediated signaling events that may negatively impact the functional activity of MAGE-A9. Inhibition of the MAPK/ERK pathway and p38 MAPK by PD98059 and SB202190, respectively, can also prevent signaling events that may negatively regulate the functional activity of MAGE-A9. The functional activity of MAGE-A9 can be enhanced by preventing the silencing of the MAGE-A9 gene via inhibition of DNA methylation by 5-Azacytidine. Other compounds such as Bay 11-7082, Rapamycin, and Y-27632 inhibit the activation of NF-κB, mTOR, and ROCK, respectively, preventing signaling events that might negatively impact MAGE-A9's functional activity. Blebbistatin, a myosin II inhibitor, can prevent the mechanical forces that might negatively influence the functional activity of MAGE-A9.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. By inhibiting proteasome activity, MG132 can prevent the degradation of MAGE-A9, thereby increasing its functional activity. It does this by directly blocking the ubiquitin-proteasome pathway, a key mechanism used by cells to degrade and recycle proteins, including MAGE-A9. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It can enhance the functional activity of MAGE-A9 by inhibiting the phosphorylation of proteins that may negatively regulate MAGE-A9. It works by directly inhibiting a wide range of protein kinases, which may phosphorylate and inactivate MAGE-A9. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, LY294002 can negate the influence of PI3K-mediated signaling events that may negatively impact the functional activity of MAGE-A9. It achieves this by directly inhibiting PI3K, a key regulator of multiple cellular processes that might influence MAGE-A9's activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can prevent signaling events that may negatively regulate the functional activity of MAGE-A9. It does this by directly inhibiting MEK, a critical kinase in the MAPK/ERK pathway, which might negatively regulate MAGE-A9. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By inhibiting histone deacetylase, it can increase the acetylation of histones associated with the MAGE-A9 gene, which can enhance the functional activity of MAGE-A9. It achieves this by directly blocking histone deacetylase, an enzyme that regulates gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By inhibiting DNA methylation, it can prevent the silencing of the MAGE-A9 gene, thereby enhancing its functional activity. It works by directly inhibiting DNA methyltransferase, an enzyme that adds methyl groups to DNA, potentially silencing MAGE-A9 gene expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 is an inhibitor of NF-κB activation. By inhibiting NF-κB, Bay 11-7082 can negate the influence of NF-κB-mediated signaling events that may negatively impact the functional activity of MAGE-A9. It achieves this by directly inhibiting the activation of NF-κB, a key regulator of multiple cellular processes that might influence MAGE-A9's activity. | ||||||
SB202190 hydrochloride | 350228-36-3 | sc-222294 sc-222294A | 1 mg 5 mg | $128.00 $495.00 | 13 | |
SB202190 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, SB202190 can prevent signaling events that may negatively regulate the functional activity of MAGE-A9. It does this by directly inhibiting p38 MAPK, a critical kinase in the MAPK pathway, which might negatively regulate MAGE-A9. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. By inhibiting mTOR, Rapamycin can negate the influence of mTOR-mediated signaling events that may negatively impact the functional activity of MAGE-A9. It achieves this by directly inhibiting mTOR, a key regulator of multiple cellular processes that might influence MAGE-A9's activity. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
Calpeptin is a calpain inhibitor. By inhibiting calpain, Calpeptin can prevent the degradation of MAGE-A9, thereby increasing its functional activity. It does this by directly blocking calpain, an enzyme involved in protein degradation, including MAGE-A9. | ||||||