Molecular structure of SB202190 hydrochloride, CAS Number: 350228-36-3
SB202190 hydrochloride (CAS 350228-36-3)
See product citations (13)
Alternate Names:
4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol Monohydrochloride
Application:
SB202190 hydrochloride is an inhibitor of the isoforms p38α and p38&beta
CAS Number:
350228-36-3
Purity:
≥96%
Molecular Weight:
367.80
Molecular Formula:
C20H14FN3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SB202190 hydrochloride is a synthetic compound used in molecular biology research due to its function as a potent and selective inhibitor of p38 MAP kinase. This kinase is involved in the cellular response to cytokines and stress, making SB202190 hydrochloride an important tool for studying inflammatory processes and signal transduction pathways. Researchers utilize this compound to elucidate the role of p38 MAP kinase in gene expression, cell cycle regulation, and apoptosis. In addition, SB202190 hydrochloride is applied in studies aimed at understanding the mechanisms of cellular adaptation to environmental stimuli. Its selectivity for the p38 MAP kinase also makes it a useful chemical for dissecting the kinase′s distinct functions from those of related kinases within the MAPK family.
SB202190 hydrochloride (CAS 350228-36-3) References
- Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase. | Hundley, TR., et al. 2001. J Immunol. 167: 1629-36. PMID: 11466386
- Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. | Studer, RK., et al. 2004. Arthritis Res Ther. 6: R56-R64. PMID: 14979938
- p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-beta. | Studer, RK. and Chu, CR. 2005. J Orthop Res. 23: 454-61. PMID: 15734262
- Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. | Chenal, J. and Pellerin, L. 2007. J Neurochem. 102: 389-97. PMID: 17394554
- Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway. | Chenal, J., et al. 2008. Eur J Neurosci. 27: 53-65. PMID: 18093179
- Brain-derived neurotrophic factor enhances the expression of the monocarboxylate transporter 2 through translational activation in mouse cultured cortical neurons. | Robinet, C. and Pellerin, L. 2010. J Cereb Blood Flow Metab. 30: 286-98. PMID: 19794395
- Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status. | Tian, J., et al. 2010. Cancer Lett. 298: 231-7. PMID: 20678860
- Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X. | Bradshaw, AC., et al. 2010. PLoS Pathog. 6: e1001142. PMID: 20949078
- Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes. | Maranto, J., et al. 2011. J Cell Biochem. 112: 1168-75. PMID: 21308746
- Selective G2/M arrest in a p53(Val135)-transformed cell line induced by lithium is mediated through an intricate network of MAPK and β-catenin signaling pathways. | Tsui, MM., et al. 2012. Life Sci. 91: 312-21. PMID: 22884810
- Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. | Börgeling, Y., et al. 2014. J Biol Chem. 289: 13-27. PMID: 24189062
- Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells. | Abdalla, MY., et al. 2015. Redox Biol. 4: 328-39. PMID: 25638774
- Adaptive response to l-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts. | Sayano, T., et al. 2016. FEBS Open Bio. 6: 303-16. PMID: 27239443
- Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria. | Woznowski, MP., et al. 2022. J Mol Med (Berl). 100: 781-795. PMID: 35451598
Inhibitor of:
DUSP22, E430002G05Rik, G3BP1, Hmcn2, JAM-C, KRTAP13-2, KRTAP19-4, Olfr550, p38 alpha, Palmdelphin, Ser/Thr Protein Kinase, and Vacuolar ATPase (V-ATPase; ATP6).Activator of:
cystatin F, DAP10, DR6, LZK, MAGE-A9, NDC1, SRMS, and UPIIIb.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB202190 hydrochloride, 1 mg | sc-222294 | 1 mg | $131.00 | |||
SB202190 hydrochloride, 5 mg | sc-222294A | 5 mg | $505.00 |