Calpeptin CAS: 117591-20-5
Calpeptin is a calpain-2, cathepsin L, and calpain-1 inhibitor.

Calpeptin (CAS 117591-20-5)

Calpeptin | CAS 117591-20-5 is rated 5.0 out of 5 by 1.
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Alternate Names: Z-Leu-norleucinal; N-Benzyloxycarbonyl-L-leucyl-norleucinal
Application: Calpeptin is a calpain-2, cathepsin L, and calpain-1 inhibitor
CAS Number: 117591-20-5
Purity: ≥98%
Molecular Weight: 362.5
Molecular Formula: C20H30N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Calpeptin is a cell permeable calpain inhibitor. Research shows that Calpeptin is an effective inhibitor of calpain 2 and can fully block cleavage of PLC-β 3 enzymes. Additionally, Calpeptin has demonstrated the ability to inhibit the activities of cathepsin L and calpain-1. In muscle cell studies Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. Pulmonary fibrosis research in mice have reported that Calpeptin can decrease expression of TGF-β1, IL-6, collage type Iα1, and angiopoietin-1 mRNA. Calpeptin is an inhibitor of Calpain 1, cathepsin K, cathepsin L and PTP. Calpeptin is an activator of Rock.


References

1. Ebisui, C., et al. 1994. Biochem. Mol. Biol. Int. 32: 515-521. PMID: 8032318
2. Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 62: 1989-1994. PMID: 8158145
3. Banno, Y. et al. 1995. J. Biol. Chem. 270: 4318-4324. PMID: 7876193
4. Bioorg. Med. Chem. Lett. (1997) 7:539-544
5. Leung, D. et al. 2000. J. Med. Chem. 43(3): 305-341. PMID: 10669559
6. Catalano, J.G. et al. 2004. Bioorg. Med. Chem. Lett. 14(1): 275-278. PMID: 14684342
7. Catalano, J.G. et al. 2004. Bioorg. Med. Chem. Lett. 14(3): 719-722. PMID: 14741275
8. Tabata, C., et al. 2010. Clin Exp Immunol. PMID: 20846163
9. Nozaki, K., et al. 2010. Exp. Neurol. 225: 430-435. PMID: 20673830
10. Formisano, L. et al. 2011. J. Pharmacol. Exp. Ther. 338(3): 997-1003. PMID: 21693630

Usage :
Stock solutions are stable for up to 2 months when stored at - 20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), DMF (5 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
86-97° C
Boiling Point :
550.66° C at 760 mmHg (Predicted)
Density :
1.08 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
Cathepsin K: IC50 = 0.11 nM (human); calpain 10: IC50 = 4 nM (rabbit); calpain 1: IC50 = 5 nM (human)
Ki Data :
Calpain 1: Ki= 7 nM (human)
pK Values :
pKa: 11.14 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
73364
MDL Number :
MFCD00155623
SMILES :
CCCC[[email protected]@H](C=O)NC(=O)[[email protected]](CC(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Calpeptin (CAS 117591-20-5)  Product Citations

See how others have used Calpeptin (CAS 117591-20-5). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 30731136  Höllerhage, M. et al. 2019. Neuropharmacology. 149: 13-26.

PMID: # 30086394  Song, Z.|Chen, H.|Xu, W.|Wu, S.|Zhu, G.| et al. 2018. Neurobiol Learn Mem. 155: 180-188.

PMID: # 30387075  Prado Spalm, FH. et al. 2018. Mol. Neurobiol.

PMID: # 28039466  Yang, T.|Fang, F.|Chen, Y.|Ma, J.|Xiao, Z.|Zou, S.|Zheng, N.|Yan, D.|Liao, S.|Chen, S.|Fang, H.|Yu, C.|Liu, J.|Dong, M.| et al. 2017. Oncotarget. 8: 9686-9695.

PMID: # 28002813  Leow, SM.|Chua, SX.|Venkatachalam, G.|Shen, L.|Luo, L.|Clement, MV.| et al. 2017. Oncotarget. 8: 16170-16189.

PMID: # 28264063  Miller, AP. et al. 2017. PLoS ONE. 12: e0173167.

PMID: # 29179452  McCarty, DJ. et al. 2017. Oncotarget. 8: 88501-88516.

PMID: # 29152136  Li, J.|Yang, S.|Zhu, G.| et al. 2017. Oncotarget. 8: 87997-88007.

PMID: # 27239756  Dos Santos, MP. et al. 2016. J. Nutr. Biochem. 34: 89-98.

PMID: # 26196320  2015. Oncotarget. 6: 27440-60.

Citations 1 to 10 of 22 total

I am trying to assess concentration of calpeptin that should be used in our in vitro studies: many papers mention a concentration of 1U/ml, however, there is no information re enzyme unit coming with your product. Could you please comment/advise? Many tha

Asked by: nickname123
Thank you for your question. The enzyme activity of sc-202516 has not been tested.
Answered by: Technical Support
Date published: 2017-12-07

Is this product stable at 4˚C? 

Asked by: hawkeye11
This chemical, Calpeptin (CAS 117591-20-5), is stable for about a month at 4˚C.
Answered by: Chemical Support 1
Date published: 2017-03-15
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Rated 5 out of 5 by from Formisano Formisano, L. et al. (PubMed 21693630) found that Calpeptin, a cell permeable calpain inhibitor, prevented cell death from exposure to Aroclor 1254. -SCBT Publication Review
Date published: 2015-03-08
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