MAGE-A1 Inhibitors
MAGE-A1 inhibitors belong to a chemical class of compounds designed to selectively interact with and modulate the activity of the MAGE-A1 protein. MAGE-A1, also known as Melanoma-Associated Antigen-A1, is a member of the cancer-testis antigen (CTA) family, which is primarily expressed in cancerous tissues and, to a limited extent, in the male germline. The precise function of MAGE-A1 in cellular processes remains an ongoing area of research. However, the development of MAGE-A1 inhibitors is centered on their ability to bind to the MAGE-A1 protein, influencing its interactions with other cellular components or its role in specific biological pathways.
In a chemical context, MAGE-A1 inhibitors can manifest as small molecules or peptides, each carefully engineered for optimal binding affinity and specificity to the MAGE-A1 protein. The overarching aim is to modulate MAGE-A1 activity within cells, an endeavor rooted in an intricate understanding of the molecular mechanisms underlying this protein's functions. Research in this domain focuses on refining the design and potency of MAGE-A1 inhibitors while unraveling the intricacies of how these compounds interact with the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound, also known as decitabine, is a cytidine analog that incorporates into DNA during replication and causes hypomethylation of DNA. This can lead to reactivation of silenced genes and may downregulate MAGE-A1 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which leads to hyperacetylation of histones, resulting in an open chromatin structure and potentially decreased MAGE-A1 expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid is also a histone deacetylase inhibitor, which may result in the downregulation of MAGE-A1 expression through similar mechanisms as Trichostatin A. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram has been shown to decrease the expression of various genes, and it may similarly affect MAGE-A1 expression, though the precise mechanisms are not fully understood. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is another histone deacetylase inhibitor, and it is known to alter gene expressions, potentially including downregulation of MAGE-A1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, and it has been shown to influence gene expression and potentially downregulate the expression of genes like MAGE-A1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone that has been studied for its ability to modulate gene expression, and it may have the potential to decrease MAGE-A1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to affect gene expression in various ways, potentially including the downregulation of MAGE-A1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate the expression of various genes, possibly including MAGE-A1. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane has been studied for its ability to influence gene expression and potentially decrease the expression of cancer-related genes like MAGE-A1. | ||||||