MAGE-A1 Antibody (MA454): sc-20033

MAGE-A1 Antibody (MA454) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAGE-A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MAGE-A1 antibody (MA454) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The melanoma-associated antigen (MAGE) family is crucial in cancer immunotherapy, as these antigens are recognized by cytotoxic T lymphocytes and are predominantly expressed in tumors, making MAGE proteins potential targets for therapeutic intervention. MAGE-A1 is known for its role in tumor rejection, showing expression in various tumor types while remaining largely absent in normal tissues, except for testis and placenta. This selective expression pattern makes MAGE-A1 valuable for distinguishing tumor cells from normal cells, offering unique opportunities for targeted cancer therapies. While extensive research exists on MAGE genes in tumors, MAGE-A1′s precise function in normal cells remains unclear, suggesting a need for further investigation into biological roles and cancer treatment applications.

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MAGE-A1 Antibody (MA454) References:

1. Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation.  |  Osterlund, C., et al. 2000. Cancer Res. 60: 1054-61. PMID: 10706124
2. A MAGE-A1 peptide is recognized on HLA-B7 human tumors by cytolytic T lymphocytes.  |  Luiten, R. and van der Bruggen, P. 2000. Tissue Antigens. 55: 149-52. PMID: 10746786
3. Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma.  |  Kobayashi, Y., et al. 2000. J Hepatol. 32: 612-7. PMID: 10782910
4. Immunoreactivity with the anti-MAGE antibody 57B in malignant melanoma: frequency of expression and correlation with prognostic parameters.  |  Busam, KJ., et al. 2000. Mod Pathol. 13: 459-65. PMID: 10786815
5. Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines.  |  Klein, C., et al. 2000. J Exp Med. 191: 1699-708. PMID: 10811863
6. Melanoma antigen genes 1 and 2 are differentially expressed in human gastric and cardial carcinomas.  |  Granelli, P., et al. 2000. Scand J Gastroenterol. 35: 528-33. PMID: 10868457
7. Genetic detection for micrometastasis in lymph node of biliary tract carcinoma.  |  Okami, J., et al. 2000. Clin Cancer Res. 6: 2326-32. PMID: 10873083
8. MAGE-A1 promotes melanoma proliferation and migration through C-JUN activation.  |  Wang, D., et al. 2016. Biochem Biophys Res Commun. 473: 959-965. PMID: 27045082
9. MAGE-A4 and MAGE-A1 Immunohistochemical Expression in High-grade Endometrial Cancer.  |  Srdelić, S., et al. 2019. Int J Gynecol Pathol. 38: 59-65. PMID: 29140883
10. MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells.  |  Mao, Y., et al. 2019. J Hematol Oncol. 12: 106. PMID: 31640756
11. The MAGE A1-A10 Expression associated with Histopathological Findings of Malignant or Non-Malignant Cells in Peripheral Lung Tumors.  |  Mastutik, G., et al. 2023. Asian Pac J Cancer Prev. 24: 2329-2335. PMID: 37505763
12. Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.  |  Mastutik, G., et al. 2024. Asian Pac J Cancer Prev. 25: 159-167. PMID: 38285780

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAGE-A1 Antibody (MA454) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-MAGE-A1 Antibody (MA454) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAGE-A1 Antibody (MA454) Specifications

Alternate Product Name: MAGE-A1

Product Clone Name: MA454

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: MAGE-A1

Epitope Species: human

Product Reactivity/Detection: MAGE-A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for MAGE-A1 Antibody (MA454): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred MAGE-A antibody is MAGE-A Antibody (6C1): sc-20034.