LYVE-1 Inhibitors
LYVE-1 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the LYVE-1 protein. LYVE-1, short for Lymphatic Vessel Endothelial Hyaluronan Receptor 1, is a cell surface receptor primarily expressed on lymphatic endothelial cells. Its primary physiological function is to bind and internalize hyaluronan, a large glycosaminoglycan molecule found abundantly in the extracellular matrix. This receptor plays a pivotal role in regulating the transport and clearance of hyaluronan in the lymphatic system, thereby influencing tissue fluid homeostasis, immune cell trafficking, and various pathological processes such as inflammation and cancer metastasis.
LYVE-1 inhibitors are designed to interfere with the interaction between LYVE-1 and hyaluronan, either by blocking the receptor's binding site or by modulating its downstream signaling pathways. By doing so, these inhibitors regulate the dynamics of hyaluronan turnover in tissues, impacting processes like tissue edema and immune cell recruitment. Researchers have been exploring the development of LYVE-1 inhibitors as tools for elucidating the precise roles of LYVE-1 in various physiological and pathological contexts. Understanding how these inhibitors affect LYVE-1 function can provide valuable insights into the complex biology of the lymphatic system and the broader implications for tissue homeostasis and disease progression. Additionally, targeting LYVE-1 with inhibitors may show promise in certain conditions, but this aspect falls beyond the scope of a description focused solely on the chemical class itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a critical role in cell growth and proliferation. By modulating this pathway, rapamycin might influence the expression of various genes, including potentially LYVE-1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methylation inhibitor that can lead to the reactivation of silenced genes. Its effects on LYVE-1 expression would depend on the epigenetic state of the LYVE-1 gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure and gene expression. It might impact LYVE-1 expression by changing the acetylation status of histones near the LYVE-1 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to modulate various signaling pathways. Its potential effects on LYVE-1 expression would likely be indirect and could involve modulation of inflammatory responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to modulate various signaling pathways. It could potentially influence LYVE-1 expression through these pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been shown to modulate various signaling pathways. Its effects on LYVE-1 expression would likely be indirect. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It might influence LYVE-1 expression indirectly through modulation of oxidative stress and inflammation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression by activating nuclear receptors. Its effects on LYVE-1 expression would depend on the presence of specific receptors and co-factors in the cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate (EGCG) is a major component of green tea. It might modulate LYVE-1 expression through its effects on signaling pathways involved in inflammation. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin inhibits the COX enzymes. While its primary action is on prostaglandin synthesis, it might have indirect effects on the expression of various genes, including potentially LYVE-1. | ||||||