LXR beta Activators
Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $140.00 $483.00 $3121.00 | ||
Another synthetic LXR agonist. Activates both LXRα and LXRβ, leading to upregulation of LXR-responsive genes. | ||||||
LXRα/β Agonist | 264206-85-1 | sc-221864 | 10 mg | $334.00 | ||
LXRα/β Agonist acts as a potent modulator of liver X receptors, engaging in specific hydrogen bonding and hydrophobic interactions within the receptor's binding pocket. This compound induces a conformational shift that enhances transcriptional activity, influencing gene expression related to cholesterol and fatty acid metabolism. Its unique ability to stabilize receptor dimers can lead to altered chromatin accessibility, thereby affecting the transcriptional landscape and cellular metabolic processes. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
Synthetic LXR agonist. Binds and activates both LXRα and LXRβ, promoting transcription of LXR target genes. | ||||||
27-Hydroxycholesterol | 20380-11-4 | sc-358756 sc-358756A sc-358756B | 5 mg 10 mg 60 mg | $350.00 $610.00 $3250.00 | 35 | |
27-Hydroxycholesterol serves as a selective LXR beta agonist, exhibiting unique interactions with the receptor that promote distinct conformational changes. This compound facilitates the recruitment of coactivators through specific electrostatic and van der Waals forces, enhancing the transcriptional regulation of genes involved in lipid homeostasis. Its role in modulating the receptor's affinity for DNA highlights its influence on metabolic pathways, potentially reshaping cellular responses to lipid levels. | ||||||
24(S)-Hydroxycholesterol | 474-73-7 | sc-471350 sc-471350A sc-471350B | 1 mg 5 mg 10 mg | $97.00 $418.00 $774.00 | 1 | |
24(S)-Hydroxycholesterol acts as a potent LXR beta modulator, engaging in specific hydrogen bonding and hydrophobic interactions that stabilize its binding to the receptor. This compound influences the receptor's dimerization and subsequent nuclear translocation, thereby altering gene expression profiles related to cholesterol metabolism. Its unique structural features enable selective activation of downstream signaling pathways, impacting cellular lipid dynamics and homeostasis. | ||||||
22(R)-hydroxycholesterol | 17954-98-2 | sc-205106 sc-205106A sc-205106B | 1 mg 5 mg 10 mg | $110.00 $357.00 $612.00 | 1 | |
An endogenous oxysterol that acts as a partial LXR agonist. | ||||||
Desmosterol | 313-04-2 | sc-214871 sc-214871A | 5 mg 10 mg | $94.00 $165.00 | 1 | |
An intermediate in cholesterol biosynthesis that can serve as an endogenous LXR ligand. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $162.00 $474.00 | 14 | |
Has been shown to increase LXRβ expression, potentially through post-transcriptional mechanisms. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Though primarily an RXR agonist, it can indirectly influence LXR activity due to the heterodimerization of LXR with RXR. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $28.00 $117.00 | ||
A primary bile acid that has been reported to influence LXR activity. | ||||||