27-Hydroxycholesterol (CAS 20380-11-4)
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27-Hydroxycholesterol, an oxysterol secreted from macrophages, may act to be capable of passing through the blood-brain barrier and entering the circulation via the brain. It may act to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol is an activator of LXR alpha and LXR beta. It has also been reported to increase levels of Abeta peptide production, reduce mitochondrial membrane potential, and induce nuclear factor kappaB (NFkappaB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is also known as (25R)-26-Hydroxycholesterol, (25R)-Cholest-5-ene-3b,26-diol, and 25(R)-27-hydroxy Cholesterol.
27-Hydroxycholesterol (CAS 20380-11-4) References
- The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | Dasari, B., et al. 2010. BMC Ophthalmol. 10: 22. PMID: 20836858
- Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. | Karuna, R., et al. 2011. Atherosclerosis. 214: 448-55. PMID: 21130455
- Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease. | Mateos, L., et al. 2011. J Alzheimers Dis. 24: 669-79. PMID: 21297254
- 27-Hydroxycholesterol: the first identified endogenous SERM. | Umetani, M. and Shaul, PW. 2011. Trends Endocrinol Metab. 22: 130-5. PMID: 21353593
- 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. | Nelson, ER., et al. 2013. Science. 342: 1094-8. PMID: 24288332
- 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. | Marwarha, G., et al. 2017. Chem Phys Lipids. 207: 108-126. PMID: 28583434
- 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. | He, S. and Nelson, ER. 2017. Maturitas. 104: 29-35. PMID: 28923174
- 27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells. | Chen, S., et al. 2019. Front Mol Neurosci. 12: 14. PMID: 30881285
- 27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction. | Wang, Y., et al. 2020. J Neuroinflammation. 17: 199. PMID: 32593306
- 27-Hydroxycholesterol, The Estrogen Receptor Modulator, Alters DNA Methylation in Breast Cancer. | Vini, R., et al. 2022. Front Endocrinol (Lausanne). 13: 783823. PMID: 35360070
- 27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis. | Li, X., et al. 2022. Oncogene. 41: 2685-2695. PMID: 35379924
- 27-Hydroxycholesterol promotes metastasis by SULT2A1-dependent alteration in hepatocellular carcinoma. | He, T., et al. 2022. Cancer Sci. 113: 2575-2589. PMID: 35599597
- The emerging role of 27-hydroxycholesterol in cancer development and progression: An update. | Abdalkareem Jasim, S., et al. 2022. Int Immunopharmacol. 110: 109074. PMID: 35978522
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
27-Hydroxycholesterol, 5 mg | sc-358756 | 5 mg | $289.00 | |||
27-Hydroxycholesterol, 10 mg | sc-358756A | 10 mg | $545.00 | |||
27-Hydroxycholesterol, 60 mg | sc-358756B | 60 mg | $3069.00 |