Molecular structure of Geranylgeraniol, CAS Number: 24034-73-9
Geranylgeraniol (CAS 24034-73-9)
See product citations (14)
Alternate Names:
Geranylgeraniol is also known as Tetraprenol.
Application:
Geranylgeraniol is an intermediate in the mevalonate pathway, shown to prevent bone-reabsorption and inhibit osteoclast formation.
CAS Number:
24034-73-9
Purity:
≥85%
Molecular Weight:
290.48
Molecular Formula:
C20H34O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol may act to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
Geranylgeraniol (CAS 24034-73-9) References
- Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis. | Montero, MT., et al. 2004. J Immunol. 173: 4936-44. PMID: 15470035
- Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. | Campia, I., et al. 2009. Br J Pharmacol. 158: 1777-86. PMID: 19888963
- Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells. | Matsubara, T., et al. 2018. In Vivo. 32: 1427-1431. PMID: 30348697
- Geranylgeraniol reverses alendronate-induced MC3T3 cell cytotoxicity and alteration of osteoblast function via cell cytoskeletal maintenance. | Patntirapong, S., et al. 2021. J Oral Pathol Med. 50: 191-199. PMID: 33164239
- Enhancing Geranylgeraniol Production by Metabolic Engineering and Utilization of Isoprenol as a Substrate in Saccharomyces cerevisiae. | Wang, J., et al. 2021. J Agric Food Chem. 69: 4480-4489. PMID: 33823596
- Timing of geranylgeraniol addition increases osteoblast activities under alendronate condition. | Mungpayabarn, H. and Patntirapong, S. 2021. J Oral Biol Craniofac Res. 11: 396-401. PMID: 34026481
- A toxicological evaluation of geranylgeraniol. | Preece, K., et al. 2021. Regul Toxicol Pharmacol. 124: 104975. PMID: 34144118
- Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation. | Saputra, WD., et al. 2021. Int J Mol Sci. 22: PMID: 34638882
- Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw. | Chen, X., et al. 2021. Front Cell Dev Biol. 9: 770899. PMID: 34805177
- In vitro Effect of Geranylgeraniol (GGOH) on Bisphosphonate-Induced Cytotoxicity of Oral Mucosa Cells. | Rattanawonsakul, K., et al. 2022. Front Oral Health. 3: 892615. PMID: 35795156
- Geranylgeraniol and Green Tea Polyphenols Mitigate Negative Effects of a High-Fat Diet on Skeletal Muscle and the Gut Microbiome in Male C57BL/6J Mice. | Shen, CL., et al. 2022. Metabolites. 12: PMID: 36295815
- Geranylgeraniol Supplementation Mitigates Soleus Muscle Atrophy via Changes in Mitochondrial Quality in Diabetic Rats. | Jiwan, NC., et al. 2022. In Vivo. 36: 2638-2649. PMID: 36309365
- Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells. | Aiuchi, T., et al. 1998. J Biochem. 124: 300-3. PMID: 9685718
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | Fisher, JE., et al. 1999. Proc Natl Acad Sci U S A. 96: 133-8. PMID: 9874784
Inhibitor of:
Lamin A, PMVK, Rho D, and RLD-1.Activator of:
βA4-crystallin, γA-crystallin, 2410131K14Rik, ABC1, ABCG5, cHMGCS, CYP46, EBP, FBL7, FXRβ, GGPS1, GGtase-α, GGTase-Iβ, GP73, HMGCR, INSIG-2, LXR alpha, LXR beta, MVD, Peroxin 3, RIP15, RLD-1, Squalene synthetase, TERE1, and TM7SF2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Geranylgeraniol, 20 mg | sc-200858 | 20 mg | $159.00 | |||
Geranylgeraniol, 100 mg | sc-200858A | 100 mg | $465.00 |