Desmosterol (CAS 313-04-2)
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Desmosterol is a naturally occurring sterol that is an intermediate in the biosynthesis of cholesterol. In research applications, desmosterol is utilized to study the intricate pathways of sterol metabolism and the regulation of cholesterol synthesis in cells. It functions as a precursor in the final steps leading to the formation of cholesterol, mediated by the enzyme 24-dehydrocholesterol reductase. Researchers are interested in desmosterol′s role within the context of sterol homeostasis and its implications on cellular membrane structure and function. Studies involving desmosterol also focus on its impact on gene expression through the activation of liver X receptors (LXRs), which are nuclear receptors that regulate the transcription of genes involved in lipid metabolism. Moreover, desmosterol serves as a biomarker in the investigation of Smith-Lemli-Opitz syndrome and other disorders of cholesterol biosynthesis. Its presence and levels in biological samples can provide insights into the functional status of the cholesterol biosynthetic pathway.
Desmosterol (CAS 313-04-2) References
- Desmosterol may replace cholesterol in lipid membranes. | Huster, D., et al. 2005. Biophys J. 88: 1838-44. PMID: 15596512
- Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. | Rodríguez-Acebes, S., et al. 2009. Biochem J. 420: 305-15. PMID: 19260826
- Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility. | Mourvaki, E., et al. 2010. Asian J Androl. 12: 862-70. PMID: 20729867
- Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? | Singh, P., et al. 2011. Biochim Biophys Acta. 1808: 2428-34. PMID: 21763272
- Alzheimer's disease: brain desmosterol levels. | Wisniewski, T., et al. 2013. J Alzheimers Dis. 33: 881-8. PMID: 23042211
- Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis. | Zerenturk, EJ., et al. 2013. Prog Lipid Res. 52: 666-80. PMID: 24095826
- Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. | Costello, DA., et al. 2016. ACS Infect Dis. 2: 852-862. PMID: 27933788
- Effects of seaweed sterols fucosterol and desmosterol on lipid membranes. | Mouritsen, OG., et al. 2017. Chem Phys Lipids. 205: 1-10. PMID: 28365392
- Cholesterol and desmosterol dancing to the beat of a different drug. | Brown, AJ. and Gelissen, IC. 2018. J Intern Med. 283: 102-105. PMID: 29178237
- Cholesterol Biosynthesis and Uptake in Developing Neurons. | Genaro-Mattos, TC., et al. 2019. ACS Chem Neurosci. 10: 3671-3681. PMID: 31244054
- Quantitative analysis of cholesterol oxidation products and desmosterol in parenteral liposomal pharmaceutical formulations. | Wang, C., et al. 2019. Int J Pharm. 569: 118576. PMID: 31362094
- Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. | Berghoff, SA., et al. 2021. Nat Neurosci. 24: 47-60. PMID: 33349711
- Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone. | Cenik, B., et al. 2022. Transl Psychiatry. 12: 139. PMID: 35379782
- Dynamic stability of cholesterol and desmosterol in human milk from four Asian countries. | Kim, J., et al. 2022. Food Sci Biotechnol. 31: 1513-1522. PMID: 36278138
- Desmosterol in rat brain myelin. | Banik, NL. and Davison, AN. 1967. J Neurochem. 14: 594-6. PMID: 6025630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desmosterol, 5 mg | sc-214871 | 5 mg | $94.00 | |||
Desmosterol, 10 mg | sc-214871A | 10 mg | $165.00 |