Molecular structure of T 0901317, CAS Number: 293754-55-9
T 0901317 (CAS 293754-55-9)
See product citations (5)
Alternate Names:
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2, 2-trifluoroethyl)benzenesulfonamide; N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
Application:
T 0901317 is a cell-permeable, nonsterol compound that acts as a highly potent LXR activator
CAS Number:
293754-55-9
Purity:
≥98%
Molecular Weight:
481.33
Molecular Formula:
C17H12NSO3F9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
T 0901317 is a cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor (LXR) agonist (EC50 of 20 nM for LXRalpha). T 0901317 is reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride. T-0901317, also referred to as T-1317, TO-091317, or TO 901317, is a potent liver X receptor (LXR) agonist that exhibits significant effects. It acts as a non-selective LXR agonist with an EC50 of approximately 50 nM. By activating both LXRα and LXRβ, T-0901317 enhances the expression of ATP binding cassette A1 (ABCA1), which is responsible for transporting cholesterol out of cells.
T 0901317 (CAS 293754-55-9) References
- Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. | Repa, JJ., et al. 2000. Science. 289: 1524-9. PMID: 10968783
- Role of LXRs in control of lipogenesis. | Schultz, JR., et al. 2000. Genes Dev. 14: 2831-8. PMID: 11090131
- Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. | DeBose-Boyd, RA., et al. 2001. Proc Natl Acad Sci U S A. 98: 1477-82. PMID: 11171976
- Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport. | Field, FJ., et al. 2002. Biochem J. 368: 855-64. PMID: 12213084
- Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. | Fukumoto, H., et al. 2002. J Biol Chem. 277: 48508-13. PMID: 12384498
- Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis. | Cao, G., et al. 2003. J Biol Chem. 278: 1131-6. PMID: 12414791
- T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. | Terasaka, N., et al. 2003. FEBS Lett. 536: 6-11. PMID: 12586329
- The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. | Chisholm, JW., et al. 2003. J Lipid Res. 44: 2039-48. PMID: 12923232
- The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. | Koldamova, RP., et al. 2005. J Biol Chem. 280: 4079-88. PMID: 15557325
- The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells. | Chuu, CP., et al. 2007. Biochem Biophys Res Commun. 357: 341-6. PMID: 17416342
- The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- mice. | Dai, XY., et al. 2008. J Cardiovasc Pharmacol. 51: 467-75. PMID: 18437096
- Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats. | Wang, D., et al. 2011. Int Immunopharmacol. 11: 2098-103. PMID: 21939782
- Resveratrol suppresses T0901317-induced hepatic fat accumulation in mice. | Gao, M. and Liu, D. 2013. AAPS J. 15: 744-52. PMID: 23591747
- A liver-X-receptor ligand, T0901317, attenuates IgE production and airway remodeling in chronic asthma model of mice. | Shi, Y., et al. 2014. PLoS One. 9: e92668. PMID: 24681543
- Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. | Baranowski, M., et al. 2014. Cell Physiol Biochem. 33: 1047-57. PMID: 24732673
Inhibitor of:
4933421E11Rik, AKR1B8, apoE, CH25H, Glucagon Receptor, INSIG-2, NRIP2, ORP-8, PRC, RIP15, RLD-1, RORγ, and RUNX1.Activator of:
3β-HSD4, A-FABP, AADACL3, ABC-A1, ABC1, ABCA, ABCA14, ABCA15, ABCG1, Abcg3, ABCG5, ACAT-1, ACAT-2, Angptl3, apoA, apoA-I, ATP-binding cassette sub-family A (ABCA), ATP8B2, B42, C17orf49_0610010K14Rik, Ces1d, CYP46, DAF-12, FXRβ, Glut1, GRAMD1A, HSDL2, LPAAT-θ, LRIF, LXR, LXR alpha, LXR beta, Mdr-3, NPC1, NR5A2, ORP-2, ORP-5, OSBP, RIP15, RLD-1, RORβ, SCD, SCD3, SCD4, SREBP-1, StARD6, TMEM195, and TMEM41A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
T 0901317, 10 mg | sc-202824 | 10 mg | $89.00 | |||
T 0901317, 50 mg | sc-202824A | 50 mg | $224.00 |