Molecular structure of LXRα/β Agonist
LXRα/β Agonist (CAS 264206-85-1)
Alternate Names:
GSK 3987
Application:
LXRα/β Agonist is a specific liver X receptor (LXR) dual agonist
CAS Number:
264206-85-1
Purity:
≥98%
Molecular Weight:
384.4
Molecular Formula:
C24H20N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LXRalpha/beta Agonist is a cell-permeable maleimide analog which acts as a potent and specific LXR (liver X receptor) dual agonist (EC50= 50 nM and 40 nM for the recruitment of SRC1 to LXRalpha and LXRbeta, respectively). It displays >50-fold selectivity for LXR over a panel of nuclear receptors, which include FXR, PPARalpha/gamma/delta, PXR, AR, ERalpha/beta, GR, and PR. This upregulates ABCA1-dependent transcriptional activity (EC50 = 80 nM) as well as inhibits LPS-stimulated secretion of the proinflammatory cytokine, IL-6, in THP-1 cells.
LXRα/β Agonist (CAS 264206-85-1) References
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- Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. | Lund, EG., et al. 2006. Biochem Pharmacol. 71: 453-63. PMID: 16325781
- Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. | Quinet, EM., et al. 2006. Mol Pharmacol. 70: 1340-9. PMID: 16825483
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- Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease. | Rangaraju, S., et al. 2018. Mol Neurodegener. 13: 24. PMID: 29784049
- Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives. | Nishioka, T., et al. 2019. Molecules. 24: PMID: 31779181
- Liver X receptors and skeleton: Current state-of-knowledge. | Goel, D. and Vohora, D. 2021. Bone. 144: 115807. PMID: 33333244
- Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs). | Slominski, AT., et al. 2021. Sci Rep. 11: 8002. PMID: 33850196
Activator of:
LXR alpha, and LXR beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LXRα/β Agonist, 10 mg | sc-221864 | 10 mg | $334.00 |