LRRC33 Inhibitors
LRRC33 inhibitors belong to a chemical class designed to interact with the protein LRRC33, which is shorthand for Leucine Rich Repeat Containing 33. This protein is characterized by the presence of leucine-rich repeat (LRR) motifs, a common structural motif in proteins that are involved in protein-protein interactions. Inhibitors in this class are typically small molecules or peptides that can specifically bind to LRRC33, affecting its function by altering its interaction with other proteins or its stability within the cell. The design of these inhibitors is grounded in the understanding of the structural biology of LRRC33, particularly the shape and charge distribution of its LRR domain, which is integral to its function.
The development of LRRC33 inhibitors is a complex process that involves the identification of key interaction sites within the protein that are amenable to inhibition. Inhibitors might work by mimicking natural ligands of LRRC33, by stabilizing the protein in an inactive conformation, or by preventing its association with other cellular components critical for its function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
This bisphosphonate can suppress osteoclast activity, potentially influencing the effects of LRRC33. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC is an antioxidant that can decrease ROS levels, which may indirectly modulate the activity of LRRC33. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
An inhibitor of flavoenzymes involved in ROS production, which may influence LRRC33's role in ROS regulation. | ||||||
Mito-TEMPO | 1569257-94-8 | sc-221945 sc-221945A | 5 mg 25 mg | $65.00 $250.00 | 136 | |
Targets mitochondrial ROS, thus potentially affecting the cellular environment in which LRRC33 operates. | ||||||
Apocynin | 498-02-2 | sc-203321 sc-203321A sc-203321B sc-203321C | 1 g 10 g 100 g 500 g | $26.00 $67.00 $114.00 $353.00 | 74 | |
By inhibiting NADPH oxidase, it reduces ROS production, potentially modulating LRRC33's role. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $127.00 $192.00 $269.00 $502.00 $717.00 $1380.00 $2050.00 | 114 | |
Inhibits STAT3, which is involved in osteoclast differentiation, possibly influencing LRRC33. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
By inhibiting the NF-kB pathway involved in osteoclastogenesis, it may have an indirect effect on LRRC33's role. | ||||||
Calcitonin, Salmon | 47931-85-1 | sc-201167 sc-201167A | 1 mg 5 mg | $151.00 $613.00 | 1 | |
Directly inhibits osteoclasts, potentially influencing the cellular context in which LRRC33 functions. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $37.00 $66.00 $230.00 $665.00 $1678.00 | 39 | |
A water-soluble analog of vitamin E and acts as an antioxidant. Might indirectly modulate LRRC33's activity by reducing ROS. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Reduces oxidative stress by acting as an alternative electron acceptor, possibly affecting the environment of LRRC33. | ||||||