Molecular structure of Apocynin, CAS Number: 498-02-2
Apocynin (CAS 498-02-2)
See product citations (74)
Alternate Names:
4′-Hydroxy-3′-methoxyacetophenone; acetovanillone
Application:
Apocynin is a methoxy-substituted catechol commonly used as an inhibitor of NADPH oxidase
CAS Number:
498-02-2
Purity:
≥98%
Molecular Weight:
166.17
Molecular Formula:
C9H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Apocynin is a methoxy-substituted catechol that is used as an inhibitor of Mox and Nox (NADPH oxidase) (IC50=10muM). Because of Abocynin′s inhibition of NADPH oxidase, ROS production is also inhibited. Studies show the compound′s ability to decrease superoxide generation in bovine pulmonary arteries as well as neutrophils and macrophages (10 mM). In experimental rats, apocynin has displayed anti-inflammatory activity and can improve endothelial function by reducing oxidative stress and improved NO bioavailability. Reportedly prevents phagocytosis of MBP (myelin) by macrophages. Also has proven to be a useful product for studying NO-regulated processes in plants.
Apocynin (CAS 498-02-2) References
- Apocynin: molecular aptitudes. | Stefanska, J. and Pawliczak, R. 2008. Mediators Inflamm. 2008: 106507. PMID: 19096513
- A possible mechanism for the apocynin-induced nitric oxide accumulation in plants. | Tossi, V., et al. 2009. Plant Signal Behav. 4: 880-2. PMID: 19847121
- Apocynin improves endothelial function and prevents the development of hypertension in fructose fed rat. | Unger, BS. and Patil, BM. 2009. Indian J Pharmacol. 41: 208-12. PMID: 20177490
- Pro-oxidant activity of apocynin radical. | Castor, LR., et al. 2010. Free Radic Biol Med. 48: 1636-43. PMID: 20304045
- Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia. | Ahmad, M., et al. 2010. Am J Physiol Heart Circ Physiol. 298: H1879-88. PMID: 20304813
- The use of apocynin inhibits osteoclastogenesis. | Soares, MPR., et al. 2019. Cell Biol Int. 43: 466-475. PMID: 30761659
- Apocynin ameliorates diabetic retinopathy in rats: Involvement of TLR4/NF-κB signaling pathway. | Wang, Y., et al. 2019. Int Immunopharmacol. 73: 49-56. PMID: 31078925
- Apocynin protects retina cells from ultraviolet radiation damage via inducing sirtuin 1. | Liu, F., et al. 2020. J Drug Target. 28: 330-338. PMID: 31479288
- Apocynin Dietary Supplementation Delays Mouse Ovarian Ageing. | Timóteo-Ferreira, F., et al. 2019. Oxid Med Cell Longev. 2019: 5316984. PMID: 31772706
- Apocynin inhibits placental TLR4/NF-κB signaling pathway and ameliorates preeclampsia-like symptoms in rats. | Sha, H., et al. 2020. Pregnancy Hypertens. 22: 210-215. PMID: 33099123
- Apocynin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | Xianchu, L., et al. 2021. Bratisl Lek Listy. 122: 78-84. PMID: 33393325
- The Effect of Apocynin on Fat Graft Survival. | Keskin, ER. and Çakan, D. 2021. Aesthetic Plast Surg. 45: 1843-1852. PMID: 33649924
- Apocynin prevents reduced myocardial nerve growth factor, contributing to amelioration of myocardial apoptosis and failure. | Jie, X., et al. 2021. Clin Exp Pharmacol Physiol. 48: 704-716. PMID: 33650189
- Protective effects of apocynin against ionizing radiation-induced hepatotoxicity in rats. | Cagin, YF., et al. 2022. Biotech Histochem. 97: 228-235. PMID: 34120545
- Apocynin attenuates diabetic cardiomyopathy by suppressing ASK1-p38/JNK signaling. | Ding, W., et al. 2021. Eur J Pharmacol. 909: 174402. PMID: 34348125
- Therapeutic effects of apocynin on ovarian ischemia-reperfusion induced lung injury. | Tanyeli, A., et al. 2022. Biotech Histochem. 97: 536-545. PMID: 35152781
- Effects of taurine and apocynin on the zone of stasis. | Öcük, Ö., et al. 2022. Burns. 48: 1850-1862. PMID: 35153109
Inhibitor of:
4933437F05Rik, AMZ2, CD200R3, CGRP1, CNOX, CYB5D1, DPP3, EPX, FOXR1, Fullerene, GCP-2, gp91-phox, gp91phox, GROα_KC, HSH2, LOC100041249, LOC643260, LPO, LRRC33, Mox, MPV17L, MrgH, NALP4A, NALP4C, NALP9C, NIBP, Nox, NOXA1, NOXRED1, Olfr250, Oxr1, p22-phox, p40-phox, p47, p67-phox, PYROXD1, Romo1, Ros, SOD-1, SOHLH1, Sptrx-2, TAO2, TEX101, VAT1L, WDR13, and WDR93.Activator of:
CDNF, ERp29, LUZP4, NOXO1, p47-phox, Sulfiredoxin, TREML1, and ZNF267.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apocynin, 1 g | sc-203321 | 1 g | $26.00 | |||
Apocynin, 10 g | sc-203321A | 10 g | $67.00 | |||
Apocynin, 100 g | sc-203321B | 100 g | $114.00 | |||
Apocynin, 500 g | sc-203321C | 500 g | $353.00 |