Molecular structure of Mito-TEMPO, CAS Number: 1569257-94-8
Mito-TEMPO (CAS 1569257-94-8)
See product citations (136)
Alternate Names:
Mito-TEMPO is known as a combination of TEMPO and triphenylphosphonium.
Application:
Mito-TEMPO is a mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties.
CAS Number:
1569257-94-8
Purity:
≥97%
Molecular Weight:
528.04
Molecular Formula:
C29H35N2O2P•Cl•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mito-TEMPO is a mitochondria-targeted antioxidant that helps protect against oxidative damage to the mitochondria. It has superoxide and alkyl radical scavenging properties. Mito-TEMPO may act to facilitate in the release of proapoptotic proteins from the mitochondria, attenuating ATP-depletion recovery-mediated necrosis and apoptosis. It may act to help block negative effects on the cardiac Na+ channel in cardiomyocytes.
Mito-TEMPO (CAS 1569257-94-8) References
- Targeting antioxidants to mitochondria by conjugation to lipophilic cations. | Murphy, MP. and Smith, RA. 2007. Annu Rev Pharmacol Toxicol. 47: 629-56. PMID: 17014364
- Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. | Liu, M., et al. 2010. Circ Res. 107: 967-74. PMID: 20724705
- SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. | Liang, HL., et al. 2010. Free Radic Biol Med. 49: 1550-60. PMID: 20736062
- Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. | Dikalov, SI. and Nazarewicz, RR. 2013. Antioxid Redox Signal. 19: 1085-94. PMID: 22443458
- Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy. | Ni, R., et al. 2016. Free Radic Biol Med. 90: 12-23. PMID: 26577173
- Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice. | Rocha, VC., et al. 2016. Cancer Chemother Pharmacol. 77: 659-62. PMID: 26712129
- Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. | Du, K., et al. 2017. Arch Toxicol. 91: 761-773. PMID: 27002509
- P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. | Khalafalla, MG., et al. 2017. J Biol Chem. 292: 16626-16637. PMID: 28798231
- Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin. | Woo, SM., et al. 2017. Oncotarget. 8: 106672-106684. PMID: 29290980
- Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress. | Liu, Y., et al. 2018. Oxid Med Cell Longev. 2018: 5828120. PMID: 29765500
- Mito-TEMPO improves development competence by reducing superoxide in preimplantation porcine embryos. | Yang, SG., et al. 2018. Sci Rep. 8: 10130. PMID: 29973637
- Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. | Du, K., et al. 2019. Arch Toxicol. 93: 163-178. PMID: 30324313
- Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. | Shetty, S., et al. 2019. Free Radic Biol Med. 136: 76-86. PMID: 30946961
- Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse. | Wang, PF., et al. 2022. Mediators Inflamm. 2022: 6394199. PMID: 35769207
Inhibitor of:
EG546368, gp91-phox, LONP1, LRRC33, PRX IV, Ros, and TMEM126A.Activator of:
Grx5, SFXN1, Tim9B, and Wolframin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mito-TEMPO, 5 mg | sc-221945 | 5 mg | $66.00 | |||
Mito-TEMPO, 25 mg | sc-221945A | 25 mg | $255.00 |