Molecular structure of Stat3 inhibitor V, stattic, CAS Number: 19983-44-9
Stat3 inhibitor V, stattic (CAS 19983-44-9)
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Alternate Names:
6-Nitrobenzo[b]thiophene-1,1-dioxide; 6-Nitrobenzo[b]thiophene-1,1-dioxide; Stat three inhibitory compound
Application:
Stat3 inhibitor V, stattic is an inhibitor of Stat3 activation
CAS Number:
19983-44-9
Purity:
>95%
Molecular Weight:
211.19
Molecular Formula:
C8H5NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stat3 inhibitor V, stattic selectively inhibits Stat3, a transcription factor activated in response to cytokines and growth factors, involved in cell growth and apoptosis. It inhibits the activation, dimerization, and nuclear translocation of Stat3, disrupting its ability to initiate transcription of target genes. Stat3 inhibitor V, stattic is used to investigate the role of Stat3 in processes such as cancer cell proliferation, survival, and invasion. By inhibiting Stat3, it reduces the expression of genes involved in angiogenesis and immune evasion, influencing tumor cell behavior. This inhibition provides insights into the signaling mechanisms underlying cancer development.
Stat3 inhibitor V, stattic (CAS 19983-44-9) References
- Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. | Schust, J., et al. 2006. Chem Biol. 13: 1235-42. PMID: 17114005
- Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | Wu, MH., et al. 2012. J Nutr Biochem. 23: 1434-9. PMID: 22285823
- JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure. | Liu, J., et al. 2012. Toxicol Sci. 129: 363-71. PMID: 22696236
- Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. | Will, B., et al. 2012. Blood. 120: 2076-86. PMID: 22753872
- JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic. | Chen, B., et al. 2013. Cell Cycle. 12: 112-21. PMID: 23255093
- IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro. | Kaneshiro, S., et al. 2014. J Bone Miner Metab. 32: 378-92. PMID: 24122251
- Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation. | Sun, J., et al. 2014. Cancer Lett. 346: 257-63. PMID: 24434654
- The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. | Tactacan, CM., et al. 2015. Mol Cancer. 14: 139. PMID: 26215634
- Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer. | Li, Q., et al. 2015. Sci Rep. 5: 16082. PMID: 26542452
- Interleukin-19 induces angiogenesis in the absence of hypoxia by direct and indirect immune mechanisms. | Kako, F., et al. 2016. Am J Physiol Cell Physiol. 310: C931-41. PMID: 27053520
- Clinical relevance of circulating anti-ENA and anti-dsDNA secreting cells from SLE patients and their dependence on STAT-3 activation. | de la Varga Martínez, R., et al. 2017. Eur J Immunol. 47: 1211-1219. PMID: 28463395
- IL-6 promotes endometrial cancer cells invasion and migration through signal transducers and activators of transcription 3 signaling pathway. | Che, Q., et al. 2019. Pathol Res Pract. 215: 152392. PMID: 30922625
- Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition. | Potts, KS., et al. 2022. Cell Rep. 41: 111825. PMID: 36516770
Inhibitor of:
β-defensin 10, 2700081O15Rik, A630033E08Rik, Abi-3, AGP-3, ASB-9, BC052484, C-MIP, C86695, CD160, CD32-B_Fc γ RIIb, CDIP, CREG2, D830046C22Rik, Dab1, Dok-3, DR1, EG229879, EG240921, EG330689, EG436336, F630003A18Rik, FCAMR, Fyb, Gads, GP49A, GRB7, Hepcidin, HSZFP36, IEX-1L, IFI-202, IFN-α1, IFN-α10, IFN-δ, IFN-γRβ, IL-11Rα, IL-16, IL-17R, IL-17RC, IL-19, IL-26, IL-27Rα, IL-29, IL-3R, IL-6Rα, ISG43, K12, KIAA0415, KIAA1958, LA-PF4, LIF, LRP1, LRRC33, MS4A4A, MTSS1, NARFL, Nkx-2.4, NTT4, OTTMUSG00000016784, PC4, Pilr-β1, PLAA, PYROXD1, Siglec-G, Skint7, SOCS-1, Spi-C, SSH2, Stat, Stat1, Stat3, Stat5a, Stat5b, TARBP1, TARM1, Tensin3, TIEG1, TIP-1, TLR10, TMC5, Transcription Factor, Trp53i13, TSLPR, versican, ZFP773, and ZNF262.Activator of:
BJ-TSA-9, BTNL8, CIS, COL8A1, cystatin 12, cystatin 13, Ets-1, FRNK, HGFL, HRT3, IFN-α21, IL-10Rβ, IL-11, IL-20Rα, IL-21R, IL-22Rα2, IL-3, IRS-4, JAK3, LAX1, Oas1e, SOCS-7, SSB-4, STAM, Stat3, TECK, Testican-1, and Tyk 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat3 inhibitor V, stattic, 25 mg | sc-202818 | 25 mg | $127.00 | |||
Stat3 inhibitor V, stattic, 100 mg | sc-202818A | 100 mg | $192.00 | |||
Stat3 inhibitor V, stattic, 250 mg | sc-202818B | 250 mg | $269.00 | |||
Stat3 inhibitor V, stattic, 500 mg | sc-202818C | 500 mg | $502.00 | |||
Stat3 inhibitor V, stattic, 1 g | sc-202818D | 1 g | $717.00 | |||
Stat3 inhibitor V, stattic, 2.5 g | sc-202818E | 2.5 g | $1380.00 | |||
Stat3 inhibitor V, stattic, 5 g | sc-202818F | 5 g | $2050.00 |