Molecular structure of Calcitonin, Salmon, CAS Number: 47931-85-1
Calcitonin, Salmon (CAS 47931-85-1)
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Alternate Names:
Thyrocalcitonin
Application:
Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties
CAS Number:
47931-85-1
Purity:
≥98%
Molecular Weight:
3431.88
Molecular Formula:
C145H240N44O48S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Calcitonin, Salmon is a calcium regulating hormone secreted from mammalian thyroid parafollicular cells and in non-mammalian species from the ultimobranchial gland. Calcitonins are single chain polypeptides containing 32 amino-acid residues, showing hypocalcaemic and hypophosphatemic action, with amino-acid structure differing amongst mammalian species. Salmon calcitonin (salcatonin is the synthetic analogue) shows a markedly different sequence to that of the higher vertebrates as well as more potent activity. Eel calcitonin (Elcatonin) possesses a similar amino acid to that of the salmon form but is more stable than natural calcitonins because of the absence of disulfide bridges.
Calcitonin, Salmon (CAS 47931-85-1) References
- THE ISOLATION AND CHARACTERIZATION OF THYROCALCITONIN. | TENENHOUSE, A., et al. 1965. Proc Natl Acad Sci U S A. 53: 818-22. PMID: 14324540
- The anti-bone-resorptive agent calcitonin also acts in vitro to directly increase bone formation and bone cell proliferation. | Farley, JR., et al. 1988. Endocrinology. 123: 159-67. PMID: 3383771
- IgG4-related disease presenting as severely symptomatic hypercalcemia: A case report and review of literature. | Han, P., et al. 2024. Int J Rheum Dis. 27: e14760. PMID: 37243936
- Interactions of oral permeation enhancers with lipid membranes in simulated intestinal environments. | Larsen, NW., et al. 2024. Int J Pharm. 654: 123957. PMID: 38430950
- High-throughput method for Peptide mapping and Amino acid sequencing for Calcitonin Salmon in Calcitonin Salmon injection using Ultra High Performance Liquid Chromatography - High Resolution Mass Spectrometry (UHPLC-HRMS) with the application of Bioinformatic tools. | Kuril, AK. and Saravanan, K. 2024. J Pharm Biomed Anal. 243: 116094. PMID: 38479303
- Calcitonin Inhibits Phenotypic Switching of Aortic Smooth Muscle Cells and Neointimal Hyperplasia through the AMP-Activated Protein Kinase/Mechanistic Target of Rapamycin Pathway. | Liu, M., et al. 2024. ACS Pharmacol Transl Sci. 7: 733-742. PMID: 38481691
- Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations. | Chang, YP., et al. 2024. Protein Sci. 33: e4952. PMID: 38501491
- Triple-Hybrid BioScaffold Based on Silk Fibroin, Chitosan, and nano-Biphasic Calcium Phosphates: Preparation, Characterization of Physiochemical and Biopharmaceutical Properties. | Phan, VHG., et al. 2024. J Pharm Sci.. PMID: 38527617
- Tuning the double lipidation of salmon calcitonin to introduce a pore-like membrane translocation mechanism. | Lund, PM., et al. 2024. J Colloid Interface Sci. 669: 198-210. PMID: 38713958
- Thyrocalcitonin: parameters of bio-assay. | Schlueter, RJ. and Caldwell, AL. 1967. Endocrinology. 81: 854-60. PMID: 6042697
- Pharmacology and therapeutic use of calcitonin. | Stevenson, JC. and Evans, IM. 1981. Drugs. 21: 257-72. PMID: 7014170
- Pharmacology of receptors for calcitonin gene-related peptide and amylin. | Poyner, D. 1995. Trends Pharmacol Sci. 16: 424-8. PMID: 8578616
- Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors. | van Rossum, D., et al. 1997. Neurosci Biobehav Rev. 21: 649-78. PMID: 9353797
Inhibitor of:
CEMP1, DMP-1, Dymeclin, Gm1045, LRRC33, MrgA4, NELL1, osteocalcin, Podocan, RAMP2, RANK, SPARCL1_Sc1, TM4SF5, and UCMA.Activator of:
ALP, ALPPL2, ANKH, C20orf123, CGRP-RCP, DC-STAMP, DSPP, IFITM5, myomegalin, NPT2, OC-STAMP, OPG, Otoconin 90, PHEX, PiT1, PiT2, PKAβ cat, STC1, and TRPV6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calcitonin, Salmon, 1 mg | sc-201167 | 1 mg | $154.00 | |||
Calcitonin, Salmon, 5 mg | sc-201167A | 5 mg | $625.00 |